In the mammalian central nervous system (CNS), fast excitatory and inhibitory synaptic transmission is mediated by AMPA and GABAA receptors, respectively. These neurotransmitter receptors are differentially segregated and sorted into distinct vesicles in the Golgi apparatus, and transported to specific domains in the plasma membrane of neurons (Gu et al., PNAS, 2016). The trafficking of AMPA and GABAA receptors is regulated by Rab GTPases and SNARE complexes. BioLegend is proud to offer a variety antibodies for neurotransmitter receptor detection including those for AMPA and GABAA receptors.

Adapted from Gu et al., PNAS, 2016.
AMPA and GABAA receptors are selectively sorted into different vesicles and targeted to excitatory or inhibitory synapses, respectively. The delivery of AMPA receptor-containing vesicles to the plasma membrane is mediated by Rab GTPase 8 (Rab8) and the SNAP25-syntaxin1-VAMP2 complex. The transport of GABAA receptor-containing vesicles to the plasma membrane is regulated by Rab8, and their fusion to the membrane is mediated by the SNAP23-syntaxin1-VAMP2 complex.

Antibodies to AMPA and GABA Receptors

Description Clone Reactivity Cat. No.
Purified anti-GluR1 Antibody N355/1 Mouse, Rat 819801
Purified anti-GluR1 Phospho (Ser845) Antibody Poly28025 Rat 802501
Purified anti-GluR2 Antibody L21/32 Human, Mouse, Rat 810501
Purified anti-GABRA1 Antibody N95/35 Human, Mouse, Rat 832301
Purified anti-GABRD Antibody N151/13 Mouse, Rat 827601
Purified anti-GABBR1 Antibody N93A/49 Human, Mouse, Rat 820801
Purified anti-GABA(B)R2 Antibody N81/2 Human, Mouse, Rat 820501
Purified anti-GABRB3 Antibody N87/25 Human, Mouse, Rat 818501

Featured Products

Antibodies for Neurotransmitter Receptor-Related Proteins
Purified anti-NMDAR1 Antibody
Purified anti-NMDAR2A Antibody
Purified anti-NMDAR2B Antibody
Purified anti-SNAP-25 Antibody
Purified anti-Syntaxin Antibody
Direct-Blot™ HRP anti-Ubiquitin Antibody
Alexa Fluor® 488, 555, 594 and 647 Goat anti-mouse IgGs
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