Loading...

APC anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
M1slash70_APC_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram) (gated on total cells).
  • M1slash70_APC_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram) (gated on total cells).
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
101211 25 µg £23
Check Availability


Need larger quantities of this item?
Request Bulk Quote
101212 100 µg £72
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Frieler RA, et al. 2017. Exp Neurol. 298:104. PubMed
  2. Combes F, et al. 2018. Neoplasia. 20:848. PubMed
  3. Lin C et al. 2019. Immunity. 50(1):137-151 . PubMed
  4. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  5. Jiang W, et al. 2017. Sci Rep. 7:6501. PubMed
  6. Schröder N, et al. 2020. J Neuroinflammation. 17:131. PubMed
  7. Garo LP, et al. 2021. Nat Commun. 12:2419. PubMed
  8. Lawson H, et al. 2021. Stem Cell Reports. 16:2784. PubMed
  9. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  10. Li F, et al. 2022. Mediators Inflamm. 2022:5782922. PubMed
  11. Hao Y, et al. 2022. Exp Ther Med. 23:350. PubMed
  12. Yang D, et al. 2022. Cell. 185:1905. PubMed
  13. Kataru RP, et al. 2021. Sci Signal. 14:. PubMed
  14. Bruggemann TR, et al. 2022. iScience. 25:105185. PubMed
  15. Chuang H, et al. 2014. Nat Commun. 5:4602. PubMed
  16. Guo H, Cooper S, Friedman A, et al. 2017. PLoS One. 10.1371/journal.pone.0150809. PubMed
  17. Chang YS, et al. 2020. Int J Mol Sci. 21:00. PubMed
  18. Chen Q, et al. 2019. Cell Stem Cell. 25(6):768-783.e6. PubMed
  19. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  20. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  21. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  22. Page N, et al. 2018. Immunity. 48:937. PubMed
  23. Frisbee AL, et al. 2019. Nat Commun. 10:2712. PubMed
  24. Sanders KA, et al. 2019. Sci Rep. 9:231. PubMed
  25. Hirata Y et al. 2018. Cell stem cell. 22(3):445-453 . PubMed
  26. Wang F, et al. 2018. Oncogenesis. 7:41. PubMed
  27. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  28. Tripathi H, et al. 2020. J Mol Cell Cardiol. 149:95. PubMed
  29. d'Errico P, et al. 2021. Nat Neurosci. Online ahead of print. PubMed
  30. Huck NA, et al. 2021. J Neurosci. 41:4349. PubMed
  31. Tang L, et al. 2021. Oncol Lett. 22:605. PubMed
  32. Almada AE, et al. 2021. Cell Reports. 34(4):108656. PubMed
  33. Kokona D, et al. 2016. Exp Eye Res. S0014-4835(16)30499-7. PubMed
  34. Oliveira-Lima OC, et al. 2015. Immunobiology. . PubMed
  35. Ebneter A, et al. 2017. Transl Vis Sci Technol. 10.1167/tvst.6.2.10. PubMed
  36. Chen Y, et al. 2018. EBioMedicine. 32:31. PubMed
  37. Misumi I et al. 2019. Cell Rep. 27(5):1387-1396 . PubMed
  38. Song C, et al. 2019. Nat Commun. 10:3745. PubMed
  39. Saleh MM, et al. 2019. Cell Host Microbe. 25:756. PubMed
  40. Hanhai Z, et al. 2021. Aging (Albany NY). 13:13108. PubMed
  41. Zhang J, et al. 2021. MedComm (Beijing). 2:256. PubMed
  42. Hewitson JP, et al. 2020. J Immunol. 204:2949. PubMed
  43. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  44. Boldison J, et al. 2020. Cell Mol Immunol. 17:843. PubMed
  45. de Groot AE, et al. 2021. Prostate. 81:629. PubMed
  46. Skinner DD, et al. 2022. Front Immunol. 13:931388. PubMed
  47. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  48. Clark K, et al. 2015. J Autoimmun. Available online 21 August 2015. PubMed
  49. O’Dea K, et al. 2016. PLoS One. 11:e0167801. PubMed
  50. Chen CC, et al. 2020. Cancer Cell. 37:71. PubMed
  51. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  52. Lutzmann M, et al. 2019. Cell Rep. 28:2851. PubMed
  53. Chow MT et al. 2019. Immunity. 50(6):1498-1512 . PubMed
  54. Chattopadhyay A, et al. 2018. Sci Rep. 8:9032. PubMed
  55. Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
  56. Oh DS, et al. 2021. Autophagy. 17:2111. PubMed
  57. Wang Q, et al. 2020. Wound Repair Regen. 28:105. PubMed
  58. Jia G, et al. 2022. Front Cell Dev Biol. 9:796757. PubMed
  59. Rogic A, et al. 2021. Nat Commun. 12:6889. PubMed
  60. Rossi DC, et al. 2021. J Clin Invest. 131:. PubMed
  61. Pack AD, et al. 2021. Cell Reports. 36:109586. PubMed
  62. Larouche JA, et al. 2021. eLife. 0.416666666666667. PubMed
  63. Yousif AS, et al. 2020. Immunity. 54(2):235-246.e5. PubMed
  64. Elbaz M, et al. 2015. Mol Oncol. 9: 906-919. PubMed
  65. Jin X, et al. 2019. Mol Cell. 73:22:00. PubMed
  66. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  67. Yamashiro LH, et al. 2020. Nat Commun. 2.806944444. PubMed
  68. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  69. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  70. Bae SH, et al. 2021. Theranostics. 11:2522. PubMed
  71. Mathur S, et al. 2021. JCI Insight. 6:. PubMed
  72. Kummer MP, et al. 2021. EMBO J. 40:e108662. PubMed
  73. Casali P, et al. 2021. Front Immunol. 12:761450. PubMed
  74. Xu M, et al. 2021. Front Physiol. 12:700338. PubMed
  75. Bell BJ, et al. 2022. Brain Behav Immun Health. 23:100478. PubMed
  76. Dolgova EV, et al. 2022. Int J Mol Sci. 23:. PubMed
  77. Xiong A, et al. 2022. EBioMedicine. 83:104239. PubMed
  78. Castiglioni A, et al. 2015. PLoS One. 10:128094. PubMed
  79. Nasser MW, et al. 2015. Cancer Res . 75: 974-985. PubMed
  80. Liu Y, et al. 2015. Sci Rep. 5:17215. PubMed
  81. Peng J, et al. 2016. Nat Commun. 7:12029. PubMed
  82. Seita Y, et al. 2020. J Alzheimers Dis. 75:45:00. PubMed
  83. Shi L, et al. 2021. Immunity. . PubMed
  84. Zhou Z, et al. 2019. Oxid Med Cell Longev. 2019:1209307. PubMed
  85. An YA et al. 2017. eLife. 6 pii: e24071. PubMed
  86. Nowak WN, et al. 2019. Mediators Inflamm. 2019:1868170. PubMed
  87. Tran L, et al. 2017. Cancer Immunol Res. 5:1141. PubMed
  88. Nakamura‐Ishizu A et al. 2018. Cell reports. 25(7):1772-1785 . PubMed
  89. Zhang X, et al. 2022. Pharmaceutics. 14:. PubMed
  90. Higa T, et al. 2022. Nat Commun. 13:1500. PubMed
  91. Zhang Z, et al. 2021. Oncoimmunology. 10:1912472. PubMed
  92. Han C, et al. 2021. Cell Reports. 34(6):108706. PubMed
  93. Lebratti T, et al. 2021. eLife. 10:00. PubMed
  94. Chew W, et al. 2016. Nat Methods. 13: 868-874. PubMed
  95. Oghumu S, et al. 2014. Immunology. 143: 109-119. PubMed
  96. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  97. Sive J, et al. 2015. Leukemia. . PubMed
  98. Eddens T, et al. 2015. J Immunol. 195: 185 - 193. PubMed
  99. Haas R 2013. J Immunol. 190:3100. PubMed
  100. McCreedy DA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  101. Yang L, et al. 2020. Cell Stem Cell. 27(1):125-136. PubMed
  102. Sato H, et al. 2020. Cell Reports. 31(5):107579. PubMed
  103. Gui J, et al. 2020. Nat Cancer. 1:603. PubMed
  104. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  105. Donlan AN, et al. 2020. Anaerobe. 66:102275. PubMed
  106. Hug S, et al. 2021. Front Immunol. 12:642867. PubMed
  107. Xiao P, et al. 2021. JCI Insight. 6:. PubMed
  108. Yu X, et al. 2022. J Extracell Vesicles. 11:e12185. PubMed
  109. Dane EL, et al. 2022. Nat Mater. 21:710. PubMed
  110. Zhou Y, et al. 2022. Nat Commun. 13:2906. PubMed
  111. Kumari A, et al. 2022. Sci Rep. 12:15273. PubMed
  112. Li P, et al. 2021. Nat Immunol. 22:1107. PubMed
  113. Uher O, et al. 2021. Cancers (Basel). 13:. PubMed
  114. Callahan SM, et al. 2021. Curr Protoc. 1:e294. PubMed
  115. Yoshida K, et al. 2022. Sci Rep. 12:17276. PubMed
  116. Syed A, et al. 2015. Infect Immun . 83: 3428-3437. PubMed
  117. Gabbita S, et al. 2015. PLoS One. 10: e0137305. PubMed
  118. Zhang Y, et al. 2020. Int J Mol Sci. 21:00. PubMed
  119. Szafran BN, et al. 2021. Chemical Research in Toxicology. 34(6):1556-1571. PubMed
  120. Dos Santos Dias L, et al. 2021. PLoS Pathog. e1009324:17. PubMed
  121. Chun E, et al. 2020. Immunity. 51(5):871-884.e6.. PubMed
  122. Di Genua C, et al. 2020. Cancer Cell. 37(5):690-704.e8.. PubMed
  123. Domingos-Pereira S, et al. 2019. Cancer Immunol Res. 7:621. PubMed
  124. Hiramoto T, et al. 2018. Mol Ther. 26:1255. PubMed
  125. Deng Z, et al. 2017. Oncogene. 36:639. PubMed
  126. Topper MJ et al. 2017. Cell. 171(6):1284-1300 . PubMed
  127. Yu VWC, et al. 2017. Cell. 168:944. PubMed
  128. Ayoub M, et al. 2019. Sci Rep. 9:6348. PubMed
  129. Perdomo J, et al. 2019. Nat Commun. 10:1322. PubMed
  130. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  131. Colliou N, et al. 2018. Gut Microbes. 9:279. PubMed
  132. Chen X et al. 2017. Cell stem cell. 21(6):747-760 . PubMed
  133. Hernández–Santos N, et al. 2018. Cell Host Microbe. 1.313194444. PubMed
  134. Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed
  135. BÖiers C, et al. 2018. Dev Cell. 44:362. PubMed
  136. Kang SJ, et al. 2022. Food Sci Anim Resour. 42:903. PubMed
  137. Sodji QH, et al. 2022. Cancer Res Commun. 2:725. PubMed
  138. Li Z, et al. 2022. J Exp Clin Cancer Res. 41:74. PubMed
  139. Hu J, et al. 2022. Cell Mol Neurobiol. . PubMed
  140. Soto-Díaz K, et al. 2021. Front Immunol. 12:734349. PubMed
  141. Scheiblich H, et al. 2021. J Immunol. 207:2143. PubMed
  142. Shcherbina A, et al. 2020. Cell Rep. 32:107964. PubMed
  143. Flommersfeld S, et al. 2021. Immunity. :. PubMed
  144. Alshetaiwi H, et al. 2020. Sci Immunol. 5:00. PubMed
  145. Honarpisheh P, et al. 2020. J Neuroinflammation. 0.9625. PubMed
  146. Peralta Ramos JM, et al. 2017. Front Immunol. 1.490277778. PubMed
  147. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  148. Xu H, et al. 2020. Immunity. 51(4):696-708.e9.. PubMed
  149. Timmons GA, et al. 2021. Front Immunol. 12:700431. PubMed
  150. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  151. Horn KJ, et al. 2022. Nat Commun. 13:3321. PubMed
  152. Lee SS, et al. 2022. Commun Biol. 5:654. PubMed
  153. Sá da Bandeira D, et al. 2022. Cell Rep. 40:111114. PubMed
  154. Grune J, et al. 2022. Nat Cardiovasc Res. 1:649. PubMed
  155. Pitsch J, et al. 2021. Ann Neurol. 89:666. PubMed
  156. Hu J, et al. 2022. J Neuroinflammation. 19:71. PubMed
  157. Miki Y, et al. 2016. J Biol Chem. 291: 15588 - 15601. PubMed
  158. Liu Y, et al. 2017. J Neurosci. 37(4):871-881. PubMed
  159. Li J, et al. 2020. Elife. 9:00. PubMed
  160. Wessel AW, et al. 2020. Nat Commun. 4.123611111. PubMed
  161. Callahan S, et al. 2020. Cell Microbiol. 22:e13210. PubMed
  162. Tang CC, et al. 2021. eLife. 10:00. PubMed
  163. Li Y, et al. 2020. Cell Stem Cell. 27(5):732-747.e7. PubMed
  164. Omori S, et al. 2021. Cell Reports. 34(6):108734. PubMed
  165. Derecka M, et al. 2020. Nat Immunol. 261:21. PubMed
  166. Morimura S, et al. 2021. Int J Mol Sci. :22. PubMed
  167. Socodato R, et al. 2020. Sci Signal. 13: . PubMed
  168. Yu LC, et al. 2020. Front Neurol. 1.104166667. PubMed
  169. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  170. Qi S et al. 2016. eLife. 5 pii: e14756. PubMed
  171. Haloul M, et al. 2019. Sci Rep. 9:14050. PubMed
  172. Booth CAG, et al. 2018. Cancer Cell. 33:274. PubMed
  173. Xu X, et al. 2018. Cell. 175:1336. PubMed
  174. Habib S, et al. 2018. Infect Immun. 86:e00019. PubMed
  175. Ishidome T et al. 2017. EBioMedicine. 22:89-99 . PubMed
  176. Zhou Z, et al. 2022. Life (Basel). 12:. PubMed
  177. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  178. Harnett MM, et al. 2022. Front Immunol. 13:953053. PubMed
  179. Yang Z, et al. 2021. Sci Adv. 7:. PubMed
  180. Shen X, et al. 2021. Front Immunol. 12:710750. PubMed
  181. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  182. Kren N, et al. 2020. Sci Rep. 10:7390. PubMed
  183. Viengkhou B, et al. 2021. J Neuroinflammation. 18:237. PubMed
  184. Mansell E, et al. 2020. Cell Stem Cell. . PubMed
  185. Hassan AO, et al. 2021. Cell Reports. 36(4):109452. PubMed
  186. Zee BM, et al. 2021. iScience. 24(6):102651. PubMed
  187. Nguyen PT, et al. 2020. Cell. 182(2):388-403.e15. PubMed
  188. Bayik D, et al. 2020. Cancer Discov. 1.256944444. PubMed
  189. Corrales L, et al. 2016. J Immunol. 196: 3191-3198. PubMed
  190. Koshida R, et al. 2015. Biochem Biophys Res Commun. 463: 109-115. PubMed
  191. Sauma D, et al. 2017. Immunol Res. 10.1007/s12026-017-8936-9. PubMed
  192. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  193. Ruan C, et al. 2020. Brain Behav Immun. 83:180. PubMed
  194. Lu P, et al. 2021. Nat Commun. 12:1042. PubMed
  195. Bugler-Lamb AR, et al. 2021. Mol Metab. 49:101197. PubMed
  196. Zhu Y, et al. 2021. EMBO J. 40:e105320. PubMed
  197. Yan W, et al. 2021. Front Med (Lausanne). 8:752223. PubMed
  198. Kim S, et al. 2021. Elife. 10:. PubMed
  199. Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed
  200. Cuesta M, et al. 2016. J Immunol. 196: 2466 - 2475. PubMed
  201. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  202. Nosho S, et al. 2020. Int J Mol Sci. 21:00. PubMed
  203. Runyan CE, et al. 2020. Aging Cell. 19:00. PubMed
  204. Burns JC, et al. 2020. eLife. 9:00. PubMed
  205. Tripathi H, et al. 2020. Stem Cell Rev Rep. 0.953472222. PubMed
  206. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  207. Liu Z, et al. 2020. Cell. 178(6):1509-1525.e19.. PubMed
  208. Yu X, et al. 2019. Nat Commun. 10:574. PubMed
  209. Xia P et al. 2018. Immunity. 48(4):688-701 . PubMed
  210. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  211. Milner MT, et al. 2022. STAR Protoc. 3:101295. PubMed
  212. Zelter T, et al. 2022. EMBO Rep. 23:e53641. PubMed
  213. Zhang X, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  214. Otvos B, et al. 2021. Clin Cancer Res. 27:2038. PubMed
  215. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  216. Ye X, et al. 2021. Cancer Biol Med. Online ahead of print. PubMed
  217. Cilenti F, et al. 2021. Immunity. . PubMed
  218. Maruoka M, et al. 2021. Molecular Cell. 81(7):1397-1410.e9. PubMed
  219. Lee J, et al. 2020. Cell Reports. 33(13):108560. PubMed
  220. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  221. Dobson HE, et al. 2020. Mucosal Immunol. 0.901388889. PubMed
  222. Cho DS, et al. 2020. J Cachexia Sarcopenia Muscle. 1.396527778. PubMed
  223. Li X, et al. 2020. Nat Commun. 4.877777778. PubMed
  224. Sun J et al. 2018. Cell stem cell. 23(3):355-369 . PubMed
  225. Goldstein JM et al. 2019. Cell reports. 27(4):1254-1264 . PubMed
  226. Ford J, et al. 2019. Front Immunol. 2.502083333. PubMed
  227. Ge C, et al. 2020. Cell Reports. 29(13):4236-4244.e3.. PubMed
  228. Akk A, et al. 2019. Mol Immunol. 114:629. PubMed
  229. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  230. Li W, et al. 2021. Cell Transplant. 30:9636897211004090. PubMed
  231. Wüthrich M, et al. 2021. MBio. 12:e0201821. PubMed
  232. Vasudevan SO, et al. 2022. Cell Rep. 39:110755. PubMed
  233. Kohn EM, et al. 2022. J Immunol. 208:1417. PubMed
  234. Wolf SJ, et al. 2022. JCI Insight. 7:. PubMed
  235. Zeng Q, et al. 2022. iScience. 25:105151. PubMed
  236. Huang J, et al. 2014. J Immunol. 192:1972. PubMed
  237. Xiong X, et al. 2015. Stroke. 46: 2271-2276. PubMed
  238. Zhang L, et al. 2021. iScience. 24(9):102942. PubMed
  239. Alam Z, et al. 2020. Cell Rep. 107825:31. PubMed
  240. Hohsfield LA, et al. 2020. J Neuroinflammation. 0.902083333. PubMed
  241. Horn LA, et al. 2017. Oncotarget. 8:57964. PubMed
  242. Tang Y, et al. 2019. Nat Commun. 10:4157. PubMed
  243. Metidji A et al. 2018. Immunity. 49(2):353-362 . PubMed
  244. Duarte D, et al. 2018. Cell Stem Cell. 22:64. PubMed
  245. Nenasheva T, et al. 2017. PLoS One. 12(6):e0178983. PubMed
  246. Ha TC, et al. 2020. Hum Gene Ther. 32:458. PubMed
  247. Howard ZM, et al. 2022. JCI Insight. 7:. PubMed
  248. Gavini CK, et al. 2022. J Neuroinflammation. 19:57. PubMed
  249. McCallion A, et al. 2022. Front Immunol. 13:961599. PubMed
  250. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  251. Mohammadi MR, et al. 2021. Commun Biol. 4:685. PubMed
  252. Chen R, et al. 2021. Cell Reports. 34(7):108751. PubMed
  253. Lowe PP, et al. 2020. J Neuroinflammation. 0.913888889. PubMed
  254. León-Cabrera S, et al. 2014. Int J Biol Sci. 9 948 . PubMed
  255. Johansson J, et al. 2013. J Neurosci. 33:16016. PubMed
  256. Uribe-Herranz M, et al. 2018. JCI Insight. 3. PubMed
  257. Vásquez M, et al. 2019. J Immunol. 203:696. PubMed
  258. Ohgomori T et al. 2019. J Comp Neurol. 528(1):14-31 . PubMed
  259. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  260. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  261. Scheiblich H, et al. 2021. Cell. 184:5089. PubMed
  262. Deng Q, et al. 2021. Gut Microbes. 13:1. PubMed
  263. Kataru RP, et al. 2022. Front Aging. 3:864860. PubMed
  264. Woodring T, et al. 2022. iScience. 25:104934. PubMed
  265. Yang YS, et al. 2022. Nat Commun. 13:6175. PubMed
  266. Gorina R, et al. 2014. J Immunol. 192:324. PubMed
  267. Liu Y, et al. 2015. BioMed Res Int. 2015 563425. PubMed
  268. Choi J, et al. 2015. PLoS One. 10: e0138592. PubMed
  269. Jaako P, et al. 2016. Leukemia. 10.1038/leu.2016.159. PubMed
  270. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  271. Wilson ZS, et al. 2020. Sci Rep. 10:2142. PubMed
  272. Kajiwara C, et al. 2018. J Immunol. 200:623. PubMed
  273. Gomes T, et al. 2019. Front Immunol. 10:2088. PubMed
  274. Liu X, et al. 2021. Int J Med Sci. 18:3125. PubMed
  275. Friker LL, et al. 2020. Cell Rep. 30:3743. PubMed
  276. Chen F, et al. 2021. J Cell Mol Med. 25:11039. PubMed
  277. Howard ZM, et al. 2021. Am J Pathol. 191:730. PubMed
  278. Luciunaite A, et al. 2020. J Neurochem. 155:650. PubMed
  279. Pi J, et al. 2022. J Nanobiotechnology. 20:36. PubMed
  280. Zheng Y, et al. 2022. J Immunol. 208:501. PubMed
  281. van Geffen C, et al. 2021. Front Immunol. 12:695933. PubMed
  282. Milich LM, et al. 2021. J Exp Med. 218:. PubMed
  283. Asadi Shahmirzadi A, et al. 2020. Cell Metabolism. 32(3):447-456.e6. PubMed
  284. Vaibhav K, et al. 2020. Sci Adv. 6:eaax8847. PubMed
  285. Prislovsky A, Strom T 2013. Exp Hematol. 41:789. PubMed
  286. Steinkühler J, et al. 2018. J Cell Sci. 132. PubMed
  287. Haruwaka K, et al. 2019. Nat Commun. 4.455555556. PubMed
  288. Ireland L, et al. 2020. Front Immunol. 11:297. PubMed
  289. Ombrato L, et al. 2021. Nat Protoc. 16:872. PubMed
  290. Kelley WJ, et al. 2022. JCI Insight. 7: . PubMed
  291. Smith KJ, et al. 2022. PLoS Biol. 20:e3001554. PubMed
  292. Jia Y, et al. 2022. Cell Discov. 8:21. PubMed
  293. Takeda K, et al. 2014. Am J Pathol. 184:686. PubMed
  294. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  295. Cerina M, et al. 2017. Brain Behav Immun. 59:103-117. PubMed
  296. Messerer DAC, et al. 2020. Front Immunol. 11:571992. PubMed
  297. Markworth JF, et al. 2020. JCI Insight. 5:00. PubMed
  298. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  299. Chung S, et al. 2020. Am J Physiol Lung Cell Mol Physiol. L921:318. PubMed
  300. Tr änkner D, et al. 2019. Cell Rep. 29:791. PubMed
  301. Kunishita Y, et al. 2020. Front Immunol. 11:98. PubMed
  302. Säwen P et al. 2018. eLife. 7 pii: e41258. PubMed
  303. Nguyen HX et al. 2017. J Neurosci. 37(38):9269-9287 . PubMed
  304. Schroder WA, et al. 2019. Sci Rep. 9:12421. PubMed
  305. Wang C, et al. 2018. Sci Transl Med. 10. PubMed
  306. Nakamura K, et al. 2018. Cancer Cell. 33:634. PubMed
  307. Hao L, et al. 2021. Br J Pharmacol. 178:4726. PubMed
  308. Fan HH, et al. 2021. Methods Mol Biol. 2276:203. PubMed
  309. Chavez JS, et al. 2022. Cells. 11:. PubMed
  310. Gao P, et al. 2021. Nat Commun. 1194:12. PubMed
  311. Ubags ND, et al. 2021. J Allergy Clin Immunol. 1049:147. PubMed
  312. Hara T, et al. 2021. Cancer Cell. 39(6):779-792.e11. PubMed
  313. Riedel SS, et al. 2021. Molecular Cell. 81(11):2332-2348.e9. PubMed
  314. Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed
  315. Fukasawa K, et al. 2016. Sci Rep. 6:30918. PubMed
  316. Andresen L, et al. 2016. PLoS One. 11: 0148428. PubMed
  317. Pelly V, et al. 2016. Mucosal Immunol. 10.1038/mi.2016.4. PubMed
  318. Jiang Y, et al. 2015. MBio. 6: e01426-15. PubMed
  319. Shi Y, et al. 2015. Mol Immunol. 66: 208-215. PubMed
  320. Thurlow LR, et al. 2018. Cell Host Microbe. 24:261. PubMed
  321. Petriello MC, et al. 2018. Toxicol Sci. 162:548. PubMed
  322. Hilt ZT, et al. 2019. JCI Insight. 4:5. PubMed
  323. Ioanna E Galani et al. 2017. Immunity. 46(5):875-890 . PubMed
  324. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  325. Zhang B, et al. 2021. Nature. 599:471. PubMed
  326. Jones GS, et al. 2020. mSphere. 5:. PubMed
  327. Xiao M, et al. 2022. Mol Oncol. 16:1026. PubMed
  328. Awida Z, et al. 2021. Int J Mol Sci. 23:. PubMed
  329. Zha ZX, et al. 2022. Acta Pharmacol Sin. :. PubMed
  330. Zhang H, et al. 2022. Commun Biol. 5:916. PubMed
  331. Li J, et al. 2022. Nat Commun. 13:1481. PubMed
  332. Shen L, et al. 2021. Cell Metabolism. 33(5):971-987.e6. PubMed
  333. Ma Y, et al. 2020. Front Immunol. 11:586685. PubMed
  334. Guenther C, et al. 2019. Front Immunol. 10:1138. PubMed
  335. Guarnerio J, et al. 2018. Nat Commun. 9:66. PubMed
  336. Li B, et al. 2019. Oncogenesis. 8:17. PubMed
  337. Omenetti S, et al. 2019. Immunity. 51:77. PubMed
  338. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
  339. Han J, et al. 2022. Cell Discov. 8:122. PubMed
  340. Schmidts A, et al. 2020. J Immunother Cancer. 8:. PubMed
  341. Sethuraman SN, et al. 2020. Theranostics. 10:3397. PubMed
  342. Hohsfield LA, et al. 2021. Elife. 10:. PubMed
  343. Zhong J, et al. 2021. Commun Biol. 4:865. PubMed
  344. Zhang J, et al. 2021. Stem Cell Res Ther. 12:579. PubMed
  345. Chang MH, et al. 2021. Cell Rep. 37:109902. PubMed
  346. Ren X, et al. 2021. Cell Death Dis. 12:484. PubMed
  347. Du Z, et al. 2020. J Allergy Clin Immunol. . PubMed
  348. Li X, et al. 2021. Cell Reports. 36(8):109607. PubMed
  349. Li J, et al. 2021. eLife. 10:00. PubMed
  350. Wan Y, et al. 2020. Cell Rep. 33:108346. PubMed
  351. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  352. Xie Y, et al. 2020. Endocrinology. 161:00:00. PubMed
  353. Hohmann A, et al. 2016. Nat Chem Biol. 10.1038/nchembio.2115. PubMed
  354. Ramos-Sevillano E, et al. 2016. PLoS One. 12: 1005500. PubMed
  355. Kolan S, et al. 2015. PLoS One. 10: 0134113. PubMed
  356. Iwata-Yoshikawa N, et al. 2014. J Virol. 88:8597. PubMed
RRID
AB_312794 (BioLegend Cat. No. 101211)
AB_312795 (BioLegend Cat. No. 101212)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Spark PLUS UV™ 395 anti-mouse/human CD11b M1/70 FC
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account