- W17233E (See other available formats)
- Regulatory Status
- Other Names
- B7-2, B70, Ly-58
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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CD86, also known as B7-2, B70, and Ly-58, is an 80 kD immunoglobulin superfamily member. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- hCD86 Recombinant protein (full)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2927850 (BioLegend Cat. No. 381002)
- Ig superfamily, single-chain transmembrane glycoprotein, 80 kD
Monocytes/macrophages, activated B cells and T cells, dendritic cells
- T Cell activation
- C-Jun, NFκB
- CD28, CD152
- Cell Type
- B cells, Dendritic cells, Macrophages, Monocytes, T cells
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
- Hathcock KS, et al. 1996. Adv Immunol. 62:131-66.
- June CH, et al. 1994. Immunol Today. 15:321-31.
- Gene ID
- 942 View all products for this Gene ID
- View information about CD86 on UniProt.org
|Purified anti-human CD86||W17233E||FC|
|APC anti-human CD86||W17233E||FC|
|Brilliant Violet 421™ anti-human CD86||W17233E||FC|
|PE/Cyanine7 anti-human CD86||W17233E||FC|
|PE anti-human CD86||W17233E||FC|
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