TGF-B TGF-B TGF-B TGF-B IL-4R STAT6 IDo IDo IDo IDo TGF-B IL-3 IL-3 SOCS VEGF STAT3 FOXP3 CD4 CTLA-4 GITR STAT3 Cell Markers Cell Markers IL-10 IL-10 IDo IL-10 IL-12 MHC CLASS II CD80 CD80 CD86 CD86 CTLA-4 CTLA-4 CTLA-4 PD-1 TRAILR CD80 CD86 B7-1 B7-2 PD-L1 B7-h1 TRAIL FasL Th1 CD8 CD8 CD4 CD25 Perforin Granzyme Galectin CTL Tregs in Tumor Escape