Tregs in Tumor Escape


In cancer, regulatory T cells (Tregs) accumulate in the tumor microenvironment and can play a role in immune suppression and tumor escape. Tregs aid in immunosuppression is through the expression and upregulation of immune checkpoint molecules, including CTLA4 and PD1, and pro-apoptotic molecules, like Fas and TRAIL. Additionally, Tregs produce cytotoxic molecules, like perforin and granzymes, leading to T cell apoptosis and suppressive cytokines, like IL-10 and TGF-β, leading to T cell anergy and APC dysfunction. Production of IL-10 and TGF- β by Tregs also results in an increase of tolerogenic dendritic cells and impairs the activation of other immune cell types.

 

Click on the poster below to view the interactive version.

 

Tregs in Tumor Escape

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