FITC anti-human CD45RB Antibody

Pricing & Availability
MEM-55 (See other available formats)
Regulatory Status
V CD45.08
Other Names
Mouse IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
Human peripheral blood lymphocytes stained with FITC anti-human CD45RB (clone MEM-55) (filled histogram) or FITC mouse IgG2b, κ isotype control (open histogram).
  • MEM-55_FITC_CD45RB_Antibody_052617
    Human peripheral blood lymphocytes stained with FITC anti-human CD45RB (clone MEM-55) (filled histogram) or FITC mouse IgG2b, κ isotype control (open histogram).
Compare all formats See FITC spectral data
Cat # Size Price Quantity Check Availability Save
310205 25 tests £70
Check Availability

Need larger quantities of this item?
Request Bulk Quote
310206 100 tests £174
Check Availability

Need larger quantities of this item?
Request Bulk Quote

CD45RB is a 180-240 kD single chain type I membrane glycoprotein. It is an exon 5 splice variant of the tyrosine phosphatase CD45. The CD45RB isoform is expressed on thymocytes, T cell subsets, B cells, monocytes/macrophages, granulocytes, and dendritic cells. CD45RB enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines. The MEM-55 antibody recognizes a silaidase-sensitive epitope of CD45.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Host Species
Human thymocytes and T lymphocytes
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Application Notes

The MEM-55 antibody is specific for a glycosylated-CD45RB epitope that is highly expressed on memory B cells and plasmablasts but not on naïve B cells. Additional reported applications (for the relevant formats) include: immunoprecipitation, Western blotting, and immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections.

Application References

(PubMed link indicates BioLegend citation)
  1. Horejsi V, et al. 1988. Folia Biol. 34:23.
  2. Bazil V, et al. 1989. Immunogenetics 29:202.
  3. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  4. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
  5. Koethe S, et al. 2011. J. Leukoc. Biol. 90:5.
Product Citations
  1. Kaneko N, et al. 2020. Cell. 183(1):143-157.e13. PubMed
  2. Koers J, et al. 2022. Front Immunol. 13:891316. PubMed
  3. Shehata L, et al. 2019. Nat Commun. 10:1126. PubMed
AB_2687313 (BioLegend Cat. No. 310205)
AB_2687314 (BioLegend Cat. No. 310206)

Antigen Details

Tyrosine phosphatases, type I transmembrane, 180-240 kD (exon 5 splicing of CD45 gene)

Thymocytes, T cell subset, B cells, monocytes/macrophages, granulocytes, dendritic cells

Enhances TCR and BCR signaling
Galectin-1, CD2, CD3, CD4
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, T cells, Thymocytes, Tregs
Biology Area
Cell Biology, Immunology, Inhibitory Molecules, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules
Antigen References

1. Thomas M. 1989. Annu. Rev. Immunol. 7:339.
2. Trowbridge I, et al. 1994. Annu. Rev. Immunol.12:85.

Gene ID
5788 View all products for this Gene ID
View information about CD45RB on

Related FAQs

There are no FAQs for this product.
Go To Top Version: 0    Revision Date: 05/30/2017

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


8999 BioLegend Way, San Diego, CA 92121
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • PE anti-human CD45RB

  • Purified anti-human CD45RB

  • FITC anti-human CD45RB

  • Alexa Fluor® 594 anti-human CD45RB

  • TotalSeq™-A0844 anti-human CD45RB

  • TotalSeq™-C0844 anti-human CD45RB Antibody

  • TotalSeq™-B0844 anti-human CD45RB


Login / Register
Remember me
Forgot your password? Reset password?
Create an Account