- S17007L (See other available formats)
- Other Names
- Rat IgG2a, κ
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CD170, also known as Siglec-F, Siglec-5, is a member of the Sialic acid-binding Ig-like lectin family, type I single pass transmembrane protein, with 4 extracellular Ig-like domains and 2 ITIM motifs in the cytoplasmic domain; preferentially binds [alpha]-2,3-linked sialic acid. Siglec F is expressed in eosinophils, alveolar macrophages and intestinal microfold (M) cells and induces apoptosis of the lung eosinophis during allergic asthma.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Member of the Sialic acid-binding Ig-like lectin family, type I, single pass, transmembrane protein, 4 extracellular Ig-like domains, 2 ITIM motifs in the cytoplasmic domain
Eosinophils, alveolar macrophages, intestinal microfold (M) cells
- Induces apoptosis in eosinophils
- [alpha]-2,3-linked sialic acid
- Cell Type
- Eosinophils, Macrophages
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Siglec Molecules
- Antigen References
- Gicheva N, et al. 2016. Biochem. Biophys. Res. Commun. 479:1.
- Kiwamoto T, et al. 2015. J. Allergy Clin. Immunol. 135:1329.
- Suzukawa M, et al. 2013. J. Immunol. 190:5939.
- Patnode ML, et al. 2013. J. Biol. Chem. 288:26533.
- Gene ID
- 233186 View all products for this Gene ID
- View information about CD170 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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