Loading...

PE anti-mouse CD170 (Siglec-F) Antibody

Pricing & Availability
Clone
S17007L (See other available formats)
Regulatory Status
RUO
Other Names
Siglec-5
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
S17007L_PE_CD170_Antibody_082018
C57BL/6 mouse splenocytes were stained with CD193 (CCR3, clone J073E5 ) APC and CD170 (Siglec-F, clone S17007L) PE (left) or Rat IgG2a, κ PE isotype control (right).
  • S17007L_PE_CD170_Antibody_082018
    C57BL/6 mouse splenocytes were stained with CD193 (CCR3, clone J073E5 ) APC and CD170 (Siglec-F, clone S17007L) PE (left) or Rat IgG2a, κ PE isotype control (right).
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
155505 25 µg £105
Check Availability


Need larger quantities of this item?
Request Bulk Quote
155506 100 µg £247
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD170, also known as Siglec-F, Siglec-5, is a member of the Sialic acid-binding Ig-like lectin family, type I single pass transmembrane protein, with 4 extracellular Ig-like domains and 2 ITIM motifs in the cytoplasmic domain; preferentially binds [alpha]-2,3-linked sialic acid. Siglec F is expressed in eosinophils, alveolar macrophages and intestinal microfold (M) cells and induces apoptosis of the lung eosinophis during allergic asthma.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  2. Ydens E, et al. 2020. Nat Neurosci. 23:676. PubMed
  3. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  4. Go DM, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:715. PubMed
  5. Mathur S, et al. 2021. JCI Insight. 6:. PubMed
  6. Fantauzzi MF, et al. 2021. ERJ Open Res. 7: . PubMed
  7. Baasch S, et al. 2021. Cell. . PubMed
  8. Guo P, et al. 2021. J Immunol. 207:408. PubMed
  9. Yadava K et al. 2019. Elife. 8 pii: e44821. PubMed
  10. Roberts LM, et al. 2021. iScience. 24:103025. PubMed
  11. Machácek T, et al. 2022. PLoS Pathog. 18:e1010302. PubMed
  12. Aktories P, et al. 2022. Cell Rep Methods. 2:100260. PubMed
  13. Penkert RR, et al. 2020. Obesity (Silver Spring). 1631:28. PubMed
  14. Rochford I, et al. 2021. Am J Physiol Lung Cell Mol Physiol. 321:L686. PubMed
  15. Chetty A, et al. 2021. Cell Host Microbe. 29:579. PubMed
  16. Li H, et al. 2021. J Clin Invest. 131:. PubMed
RRID
AB_2750234 (BioLegend Cat. No. 155505)
AB_2750235 (BioLegend Cat. No. 155506)

Antigen Details

Structure
Member of the Sialic acid-binding Ig-like lectin family, type I, single pass, transmembrane protein, 4 extracellular Ig-like domains, 2 ITIM motifs in the cytoplasmic domain
Distribution

Eosinophils, alveolar macrophages, intestinal microfold (M) cells

Function
Induces apoptosis in eosinophils
Ligand/Receptor
[alpha]-2,3-linked sialic acid
Cell Type
Eosinophils, Macrophages
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Innate Immunity
Molecular Family
CD Molecules, Siglec Molecules
Antigen References
  1. Gicheva N, et al. 2016. Biochem. Biophys. Res. Commun. 479:1.
  2. Kiwamoto T, et al. 2015. J. Allergy Clin. Immunol. 135:1329.
  3. Suzukawa M, et al. 2013. J. Immunol. 190:5939.
  4. Patnode ML, et al. 2013. J. Biol. Chem. 288:26533.
Gene ID
233186 View all products for this Gene ID
UniProt
View information about CD170 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 08/21/2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-mouse CD170 (Siglec-F)

  • FITC anti-mouse CD170 (Siglec-F)

  • PE anti-mouse CD170 (Siglec-F)

  • APC anti-mouse CD170 (Siglec-F)

  • Brilliant Violet 421™ anti-mouse CD170 (Siglec-F)

  • Biotin anti-mouse CD170 (Siglec-F)

  • TotalSeq™-A0431 anti-mouse CD170 (Siglec-F)

  • TotalSeq™-C0431 anti-mouse CD170 (Siglec-F)

  • TotalSeq™-B0431 anti-mouse CD170 (Siglec-F)

  • Alexa Fluor® 647 anti-mouse CD170 (Siglec-F) Antibody

  • KIRAVIA Blue 520™ anti-mouse CD170 (Siglec-F) Antibody

  • Alexa Fluor® 488 anti-mouse CD170 (Siglec-F) Antibody

  • PerCP/Cyanine5.5 anti-mouse CD170 (Siglec-F) Antibody

  • PE/Cyanine7 anti-mouse CD170 (Siglec-F) Antibody

  • PE/Dazzle™ 594 anti-mouse CD170 (Siglec-F) Antibody

  • APC/Cyanine7 anti-mouse CD170 (Siglec-F)
ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account