Biotin anti-human CD336 (NKp44) Antibody

Pricing & Availability
P44-8 (See other available formats)
Regulatory Status
Other Names
NKp44, NCR2, Activating NK receptor NKp44, natural cytotoxicity triggering receptor 2. lymphocyte antigen 95 homolog
Mouse IgG1, κ
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Product Citations
Human PBMCs were stimulated with rhIL-2 for 9 days, then stained with CD56 APC and biotinylated P44-8, followed by Sav-PE
  • P44-8_Biotin_071007
    Human PBMCs were stimulated with rhIL-2 for 9 days, then stained with CD56 APC and biotinylated P44-8, followed by Sav-PE
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325106 100 µg £157
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CD336 is also known as activating NK receptor NKp44 (NKp44), natural cytotoxicity triggering receptor 2, and lymphocyte antigen 95 homolog. It is a type I transmembrane protein, member of the natural cytotoxicity receptor family that contains one immunoglobulin-like domain. NKp44 has an apparent molecular weight of 44 kD and three isoforms are produced by alternative splicing. NKp44 is expressed on IL-2 activated NK cells and a subset of γ/δ T cells. NKp44 enhances NK cell mediated cytolysis of virus infected cells and tumor cells. NKp44 has been shown to associate with the intracellular adaptor DAP12.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Host Species
recombinant human NKp44
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The p44-8 antibody against human NKp44 has been shown to be useful for flow cytometry, stimulation of human NK cells via NKp44 in a redirected lysis assay, and blocking of NKp44 function in solution. Additional reported applications (for the relevant formats) include: stimulation of human NK cells via NKp44 in a redirected lysis assay, and blocking of NKp44 function in solution1,2. The LEAF™ purified antibody (Endotoxin < 0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 325104).

Application References

(PubMed link indicates BioLegend citation)
  1. Sommaggio R, et al. 2012. J. Immunol. 188:2075. (Block)
  2. Hoechst B, et al. 2009. Hepatology. 50:799. (Block) PubMed
  3. Correia DV, et al. 2011. Blood. 118:992. (FC) PubMed
Product Citations
  1. Spaan M, et al. 2016. J Infect Dis. 213: 216 - 223. PubMed
  2. Castleman MJ, et al. 2019. Front Immunol. 0.867361111. PubMed
  3. Zeis P, et al. 2020. Immunity. 53:775. PubMed
  4. Hernndez DC, et al. 2021. Immunity. :. PubMed
  5. Marquardt N, et al. 2015. J Immunol. 194:2467. PubMed
AB_756098 (BioLegend Cat. No. 325106)

Antigen Details

Type I transmembrane protein, member of the natural cytotoxicity receptor family, contains one immunoglobulin-like domain. Approximately 44 kD. Three isoforms produced by alternative splicing.

IL-2 activated NK cells and cell lines, some γ/δ T cells activated in vitro

NK cell triggering of cytolysis toward tumor targets and other target cells deficient in MHC class I molecules
Cell Type
NK cells, T cells
Biology Area
Molecular Family
CD Molecules
Antigen References

1. Cantoni C, et al. 1999. J. Exp. Med. 189:787.
2. Allcock RJN, et al. 2003. Eur. J. Immunol. 33:567.
3. Cantoni C, et al. 2003. Structure. 11:725.

Gene ID
9436 View all products for this Gene ID
View information about CD336 on

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 2    Revision Date: 05/08/2013

For Research Use Only. Not for diagnostic or therapeutic use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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