- Poly6275 (See other available formats)
- Regulatory Status
- Other Names
- Vascular endothelial growth factor, vasculotropin, vascular permeability factor
- Rabbit Polyclonal IgG
- Ave. Rating
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- Product Citations
|Cat #||Size||Price||Quantity Check Availability||Save|
|627501||50 µl (5 Western blots)||$100.00|
VEGF, also known as vascular endothelial growth factor, vasculotropin, and vascular permeability factor, is a widely expressed mitogen for vascular endothelial cells that has been shown to promote angiogenesis and increase permeability of capillary blood vessels. VEGF is a member of the platelet-derived growth factor (PDGF) family and is produced as a homodimeric protein with approximate molecular weights of 34-46 kD. The variance in molecular weight is a result of alternative splicing events that encode monomeric proteins having 121, 165, 189 or 206 amino acids. VEGF121 and VEGF165 are secreted proteins whereas VEGF189 and VEGF206 are strongly cell-associated. VEGF binds to VEGF-R1 (also known as Flt-1) and VEGF-R2 (also known as KDR). Inhibition of VEGF biding to VEGF-Rs has been the focus of a number of tumor therapeutic strategies. The Poly6275 antibody recognizes the N-terminal region of human VEGF has been shown to be useful for Western blotting of both reduced and non-reduced VEGF.Product Details
- Antibody Type
- Host Species
- Peptide mapping to a domain near the N-terminus
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.1% sodium azide and 0.2% gelatin.
- The antibody was purified by antigen-affinity chromatography.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This product may contain other non-IgG subtypes.
- Product Citations
AB_2272658 (BioLegend Cat. No. 627501)
- Contains 8 cysteine residues involved in intra- and inter-chain disulfide bonds, platelet-derived growth factor (PDGF) family, produced as a homodimeric protein with an approximate molecular weight of 34-46 kD. Human VEGF is alternatively spliced to encod
- Mitogen for vascular endothelial cells, promotes angiogenesis and increases permeability of capillary blood vessels
- Heparin, many other proteins
- VEGF-R1 (Flt-1) and VEGF-R2 (KDR)
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
1. Connolly DT, et al. 1989. J. Clin. Invest. 84:1470.
2. Drake CJ, et al. 1995. Proc. Natl. Acad. Sci. USA 92:7657.
3. Houck KA, et al. 1991. Mol. Endocrinol. 5:1806.
- Gene ID
- 7422 View all products for this Gene ID
- View information about VEGF on UniProt.org
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