Purified anti-mouse IL-21R Antibody

Pricing & Availability
Clone
4A9 (See other available formats)
Regulatory Status
RUO
Other Names
IL-21 Receptor
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
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131902 500 µg $330
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Description

The IL-21R is a member of the cytokine receptor family that closely resembles IL-2R beta and IL-4R alpha. IL-21R is expressed by all mature lymphocytes and up-regulated after B and/or T cell activation, with the highest expression by activated B cells. A functional IL-21R consists of the IL-21R subunit and the commone gamma-chaiin. Upon binding to IL-21, it activates Jak-1, Jak-3, STAT1, STAT3 and STAT 5 transduction pathway.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Rat YB2/0 hybridoma transfectant cell line expressing truncated IL-21R
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Jin H, et al. 2004. J. Immunol. 173:657. (FC)
  2. Jin H and Malek T. 2006. J. Leukocyte Biol. 80:1416. (FC IP)
RRID
AB_1279435 (BioLegend Cat. No. 131902)

Antigen Details

Structure
A member of the class 1 cytokine receptor family. Show significant sequence and structural homology with the IL-4R alpha chain.
Distribution

Express on all mature lymphocytes including B cells, T cells, and NK cells. Reported to be up-regulated upon activation and highest expression on follicular B cells.

Ligand/Receptor
IL-21
Cell Type
B cells, Lymphocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1.Mehta DS, et al. 2004. Immu Reviews 202:84

Gene ID
60504 View all products for this Gene ID
UniProt
View information about IL-21R on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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