Purified anti-mouse IL-21R Antibody

Pricing & Availability
4A9 (See other available formats)
Regulatory Status
Other Names
IL-21 Receptor
Rat IgG2a, κ
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Product Citations
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131902 500 µg $330
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The IL-21R is a member of the cytokine receptor family that closely resembles IL-2R beta and IL-4R alpha. IL-21R is expressed by all mature lymphocytes and up-regulated after B and/or T cell activation, with the highest expression by activated B cells. A functional IL-21R consists of the IL-21R subunit and the commone gamma-chaiin. Upon binding to IL-21, it activates Jak-1, Jak-3, STAT1, STAT3 and STAT 5 transduction pathway.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
Rat YB2/0 hybridoma transfectant cell line expressing truncated IL-21R
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested
IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Jin H, et al. 2004. J. Immunol. 173:657. (FC)
  2. Jin H and Malek T. 2006. J. Leukocyte Biol. 80:1416. (FC IP)
AB_1279435 (BioLegend Cat. No. 131902)

Antigen Details

A member of the class 1 cytokine receptor family. Show significant sequence and structural homology with the IL-4R alpha chain.

Express on all mature lymphocytes including B cells, T cells, and NK cells. Reported to be up-regulated upon activation and highest expression on follicular B cells.

Cell Type
B cells, Lymphocytes
Biology Area
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1.Mehta DS, et al. 2004. Immu Reviews 202:84

Gene ID
60504 View all products for this Gene ID
View information about IL-21R on UniProt.org

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Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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