- 4A9 (See other available formats)
- Regulatory Status
- Other Names
- IL-21 Receptor
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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The IL-21R is a member of the cytokine receptor family that closely resembles IL-2R beta and IL-4R alpha. IL-21R is expressed by all mature lymphocytes and up-regulated after B and/or T cell activation, with the highest expression by activated B cells. A functional IL-21R consists of the IL-21R subunit and the commone gamma-chaiin. Upon binding to IL-21, it activates Jak-1, Jak-3, STAT1, STAT3 and STAT 5 transduction pathway.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Rat YB2/0 hybridoma transfectant cell line expressing truncated IL-21R
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Jin H, et al. 2004. J. Immunol. 173:657. (FC)
- Jin H and Malek T. 2006. J. Leukocyte Biol. 80:1416. (FC IP)
AB_2295868 (BioLegend Cat. No. 131909)
AB_2124133 (BioLegend Cat. No. 131910)
- A member of the class 1 cytokine receptor family. Show significant sequence and structural homology with the IL-4R alpha chain.
- Express on all mature lymphocytes including B cells, T cells, and NK cells. Reported to be up-regulated upon activation and highest expression on follicular B cells.
- Cell Type
- B cells, Lymphocytes
- Biology Area
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
1.Mehta DS, et al. 2004. Immu Reviews 202:84
- Gene ID
- 60504 View all products for this Gene ID
- View information about IL-21R on UniProt.org
|Purified anti-mouse IL-21R||4A9||FC, IP|
|PE anti-mouse IL-21R||4A9||FC|
|PE/Cyanine5 anti-mouse IL-21R||4A9||FC|
|APC anti-mouse IL-21R||4A9||FC|
|TotalSeq™-C0879 anti-mouse IL-21R||4A9||PG|
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