- Clone
- 11C1 (See other available formats)
- Other Names
- TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with CD19 APC and CD268 (clone 11C1) PerCP/Cyanine5.5 (top) or mouse IgG1, κ PerCP/Cyanine5.5 isotype control (bottom). -
| Cat # | Size | Price | Quantity Avail. | Save | ||
|---|---|---|---|---|---|---|
| 316917 | 25 tests | $150 | ||||
| 316918 | 100 tests | $325 | ||||
B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.
Product DetailsProduct Details
- Reactivity
- Human, African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- BAFF-R-L1.2 transfectants
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.
- Concentration
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm. - Additional Product Notes
- BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions.
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Application References
(PubMed link indicates BioLegend citation) -
- Ng LG, et al.2004. J. Immunol. 173:807. (FC IHC)
- Personal communication. (Block)
- RRID
-
AB_2565590 (BioLegend Cat. No. 316917)
AB_2565591 (BioLegend Cat. No. 316918)
Antigen Details
- Structure
- Type III transmembrane protein, TNF receptor superfamily, 19 kD
- Distribution
-
Mature B cells, B cell lymphoma, T cell subset
- Function
- Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation
- Ligand/Receptor
- BAFF/BLys, associate with TRAF3
- Cell Type
- B cells, Leukemia, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Thompson JS, et al. 2001. Science 293:2108.
2. Ng LG, et al.2004. J. Immunol. 173:807.
3. Rodig SJ, et al. 2005. Human Pathol. 36:1113.
4. Ye Q, et al. 2004. Eur. J. Immunol. 34:2750.
5. Kayagaki N, et al. 2002 Immunity 17:515. - Gene ID
- 115650 View all products for this Gene ID
- UniProt
- View information about CD268 on UniProt.org
Related Pages & Pathways
Pathways
Related FAQs
- How stable is PerCP/Cyanine5.5 tandem as compared to PerCP alone?
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PerCP/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.
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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
