TNF Superfamily Pathway

TNF-α is secreted by macrophages, monocytes, neutrophils, T cells, and NK cells. TNF-α forms multimeric complexes; stable trimers are most common in solution. TNF-α binding to surface receptors elicits a wide array of biological activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorrhagic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.

 

Click on the poster below to view the interactive version.

 

TNF Superfamily Pathway

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