Tim Tim Tim Tim Tim Tim Tim Tim NF-kB Caspase JNK1 c-Fos c-Jun DcR1 DcR2 Dr4 Dr5 Dr3 Fas CD258 ras RANK1 BAFF APRIL TWEAK TWEAK CD253 PI3 p38 NF-kB TNFR2 TNFR2 TNF-a TNF-a CD40 CD30 CD27 OX-40 OX-40L LTB BARF TACI SRC Phosphotyrosine 4-1BB1 4-1BB GITRL GITR MEK CD154 FN14 CD30L CD70 FasL Tim HVEM NGF TNF Superfamily Pathway