- Clone
- 11C1 (See other available formats)
- Other Names
- TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with Brilliant Violet 421™ anti-human CD19 and with biotinylated anti-human CD268 (clone 11C1; top) or biotinylated mouse IgG1, κ isotype control; (bottom) followed by Streptavidin PE. -
| Cat # | Size | Price | Quantity Avail. | Save | ||
|---|---|---|---|---|---|---|
| 316924 | 100 µg | $225 | ||||
B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.
Product DetailsProduct Details
- Reactivity
- Human, African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- BAFF-R-L1.2 transfectants
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Ng LG, et al.2004. J. Immunol. 173:807. (FC IHC)
- Personal communication. (Block)
- RRID
-
AB_2716222 (BioLegend Cat. No. 316924)
Antigen Details
- Structure
- Type III transmembrane protein, TNF receptor superfamily, 19 kD
- Distribution
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Mature B cells, B cell lymphoma, T cell subset
- Function
- Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation
- Ligand/Receptor
- BAFF/BLys, associate with TRAF3
- Cell Type
- B cells, Leukemia, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Thompson JS, et al. 2001. Science 293:2108.
2. Ng LG, et al.2004. J. Immunol. 173:807.
3. Rodig SJ, et al. 2005. Human Pathol. 36:1113.
4. Ye Q, et al. 2004. Eur. J. Immunol. 34:2750.
5. Kayagaki N, et al. 2002 Immunity 17:515. - Gene ID
- 115650 View all products for this Gene ID
- UniProt
- View information about CD268 on UniProt.org
Related Pages & Pathways
Pathways
Related FAQs
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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