Biotin anti-human CD268 (BAFF-R) Antibody

Pricing & Availability
Clone
11C1 (See other available formats)
Other Names
TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
11C1_Biotin_CD268_Antibody_1_092117
Human peripheral blood lymphocytes were stained with Brilliant Violet 421™ anti-human CD19 and with biotinylated anti-human CD268 (clone 11C1; top) or biotinylated mouse IgG1, κ isotype control; (bottom) followed by Streptavidin PE.
  • 11C1_Biotin_CD268_Antibody_1_092117
    Human peripheral blood lymphocytes were stained with Brilliant Violet 421™ anti-human CD19 and with biotinylated anti-human CD268 (clone 11C1; top) or biotinylated mouse IgG1, κ isotype control; (bottom) followed by Streptavidin PE.
  • 11C1_Biotin_CD268_Antibody_2_092117
Cat # Size Price Quantity Avail. Save
316924 100 µg $225
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Description

B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.

Product Details
Technical data sheet

Product Details

Reactivity
Human, African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
BAFF-R-L1.2 transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Ng LG, et al.2004. J. Immunol. 173:807. (FC IHC)
  2. Personal communication. (Block)
RRID
AB_2716222 (BioLegend Cat. No. 316924)

Antigen Details

Structure
Type III transmembrane protein, TNF receptor superfamily, 19 kD
Distribution

Mature B cells, B cell lymphoma, T cell subset

Function
Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation
Ligand/Receptor
BAFF/BLys, associate with TRAF3
Cell Type
B cells, Leukemia, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Thompson JS, et al. 2001. Science 293:2108.
2. Ng LG, et al.2004. J. Immunol. 173:807.
3. Rodig SJ, et al. 2005. Human Pathol. 36:1113.
4. Ye Q, et al. 2004. Eur. J. Immunol. 34:2750.
5. Kayagaki N, et al. 2002 Immunity 17:515.

Gene ID
115650 View all products for this Gene ID
UniProt
View information about CD268 on UniProt.org

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 0    Revision Date: 09/21/2017

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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