PE anti-mouse CD137 Antibody

Pricing & Availability
17B5 (See other available formats)
Regulatory Status
Other Names
4-1BB, TNFRSF9, Ly-63, ILA (Induced by Lymphocyte Activation), CD137
Syrian Hamster IgG
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Product Citations
Con A-stimulated (3 days) splenocytes stained with 17B5 PE
  • 17b5
    Con A-stimulated (3 days) splenocytes stained with 17B5 PE
Compare all formats See PE spectral data
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106105 50 µg $104
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106106 200 µg $317
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CD137 is a 39 kD TNF-receptor superfamily member also known as 4-1BB, TNFRSF9, Ly-63, and ILA (Induced by Lymphocyte Activation). CD137 is expressed as monomers, dimers, and tetramers on activated T and B cells. Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation. The 17B5 antibody has been reported to block 4-1BBL costimulated T cell proliferation.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
Syrian Hamster
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: in vitro blocking of 4-1BB-mediated T cell proliferation2. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 106108).

Application References

(PubMed link indicates BioLegend citation)
  1. Lee SW, et al. 2005. J. Immunol. 174:6803. (FC)
  2. Zheng G, et al. 2004. J. Immunol. 173:2428. (Block)
  3. Zheng H and G. G. Meadows 2005. J. Leukocyte Biol. 78:1070. (FC) PubMed
  4. Nishimoto H, et al. 2005. Blood 106:4241. (FC)
  5. del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
Product Citations
  1. Mulder R, et al. 2017. Front Immunol. 1.464583333. PubMed
  2. Shitaoka K, et al. 2018. Cancer Immunol Res. 6:378. PubMed
  3. Dúcka M, et al. 2021. Neoplasia. 23:326. PubMed
  4. Cannons JL, et al. 2021. Cell Rep. 37:109804. PubMed
  5. Toomer G, et al. 2022. Viruses. 14:. PubMed
  6. Ma C, et al. 2018. Science. 360:eaan5931. PubMed
  7. Marangoni F, et al. 2021. Cell. . PubMed
  8. Etxeberria I, et al. 2020. Cancer Cell. 36(6):613-629. PubMed
  9. Meadows H 2005. J Leukoc Biol. 78:1070. PubMed
  10. Marcus A et al. 2018. Immunity. 49(4):754-763 . PubMed
  11. Shen M, et al. 2022. Nat Cancer. 3:60. PubMed
  12. Pérez-Guijarro E, et al. 2020. Nat Med. 26:781. PubMed
  13. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  14. Németh T, et al. 2014. Fungal Genet Biol. 65:48. PubMed
  15. Kim SI, et al. 2020. Molecular Cancer Therapeutics. 20(1):173-182. PubMed
AB_2205693 (BioLegend Cat. No. 106105)
AB_2287565 (BioLegend Cat. No. 106106)

This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

Antigen Details

TNF-R superfamily, 39 kD

Activated T cells and B cells

T-B cell costimulation
4-1BB ligand (CDw137L)
Cell Type
B cells, T cells, Tregs
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Alderson MR, et al. 1994. Eur. J. Immunol. 24:2219.
3. Schwarz H, et al. 1996. Blood 87:2839.

Gene ID
21942 View all products for this Gene ID
View information about CD137 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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