- 17B5 (See other available formats)
- Regulatory Status
- Other Names
- 4-1BB, TNFRSF9, Ly-63, ILA (Induced by Lymphocyte Activation), CD137
- Syrian Hamster IgG
- Ave. Rating
- Submit a Review
- Product Citations
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CD137 is a 39 kD TNF-receptor superfamily member also known as 4-1BB, TNFRSF9, Ly-63, and ILA (Induced by Lymphocyte Activation). CD137 is expressed as monomers, dimers, and tetramers on activated T and B cells. Interaction of CD137 with its ligand, 4-1BBL (CD137L), is important in T-B cell costimulation. The 17B5 antibody has been reported to block 4-1BBL costimulated T cell proliferation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Syrian Hamster
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: in vitro blocking of 4-1BB-mediated T cell proliferation2. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 106108).
(PubMed link indicates BioLegend citation)
- Product Citations
AB_313240 (BioLegend Cat. No. 106103)
AB_313241 (BioLegend Cat. No. 106104)
This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.
- TNF-R superfamily, 39 kD
Activated T cells and B cells
- T-B cell costimulation
- 4-1BB ligand (CDw137L)
- Cell Type
- B cells, T cells, Tregs
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Alderson MR, et al. 1994. Eur. J. Immunol. 24:2219.
3. Schwarz H, et al. 1996. Blood 87:2839.
- Gene ID
- 21942 View all products for this Gene ID
- View information about CD137 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
|Biotin anti-mouse CD137||17B5||FC|
|PE anti-mouse CD137||17B5||FC|
|APC anti-mouse CD137||17B5||FC|
|TotalSeq™-A0194 anti-mouse CD137||17B5||PG|
|Ultra-LEAF™ Purified anti-mouse CD137||17B5||FC,Block|
|TotalSeq™-C0194 anti-mouse CD137||17B5||PG|
|TotalSeq™-B0194 anti-mouse CD137||17B5||PG|
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