- BJ40 (See other available formats)
- Regulatory Status
- Other Names
- Blast-1, SLAMF2, HuLy-m3
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD48 is a 40-47 kD GPI-anchored membrane protein, also known as Blast-1 and HuLy-m3. It is a member of the CD2 family that contains 2 IgSF domains and is widely expressed on both resting and activated hematopoietic cells with the exception of granulocytes, platelets, and erythrocytes. CD48 binds to CD2 at a considerably (>100-fold) lower affinity than CD58. It is thought to contribute to T cell activation. The cytoplasmic tail of CD48 has been shown to bind to the kinases Lck and Fyn.Product Details
- Human, African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, it is recommended to use at ≤ 2.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation.
(PubMed link indicates BioLegend citation)
- Kishimoto T, et al. 1997. Leucocyte Typing VI:White Cell Differentiation Antigens. Garland Publishing Inc.
- Wang R, et al. 2012. J. Leukoc Biol. 91:299. PubMed
- Product Citations
AB_1227561 (BioLegend Cat. No. 336702)
- CD2 family, contains 2 IgSF domains, GPI-membrane anchored, 40-47 kD
Widely expressed on hematopoietic cells except granulocytes, platelets, and erythrocytes. Increased on T and B cells after activation
- Contributes to T cell antigen recognition
- Cell Targets
- Lck, Fyn interact with cytoplasmic domain
- Cell Type
- B cells
- Biology Area
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
- Fisher RC and Thorley-Lawson DA. 1991. Mol. Cell. Biol. 11:1614.
- Korinek V, et al. 1991. Immunogenetics 33:108.
- Leukocyte Typing IV. Knapp W, et al. (Eds) Oxford University Press (1989)
- Leukocyte Typing V. Schlossman S, et al. (Eds) Oxford University Press (1995)
- Gene ID
- 962 View all products for this Gene ID
- View information about CD48 on UniProt.org
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