Purified anti-human CD185 (CXCR5) Recombinant Antibody

Pricing & Availability
Clone
QA21A13 (See other available formats)
Regulatory Status
RUO
Other Names
BLR1, MDR15
Isotype
Mouse IgG1, κ
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Product Citations
publications
QA21A13_PURE_CD185_Antibody_032522
Human peripheral blood lymphocytes were stained with purified anti-human CXCR5 recombinant (clone QA21A13) (left) or purified mouse IgG1, κ isotype control (right) followed by goat anti-mouse IgG PE.
  • QA21A13_PURE_CD185_Antibody_032522
    Human peripheral blood lymphocytes were stained with purified anti-human CXCR5 recombinant (clone QA21A13) (left) or purified mouse IgG1, κ isotype control (right) followed by goat anti-mouse IgG PE.
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382402 100 µg £182
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Description

CD185, also known as CXCR5, is a 42 kD G-protein coupled receptor with seven transmembrane regions. CXCR5 is expressed by mature B cells, follicular helper T cells, Burkitt’s lymphoma cells and a subset of neurons, and mediates cell migration to the B cell follicles in the secondary lymphoid organs. The ligand of CXCR5 is CXCL13 (BLC).

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
PBS, pH 7.2, containing 50 mM sodium citrate and 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone QA21A13 can completely block the binding of clone J252D4 on target cells.

RRID
AB_2927811 (BioLegend Cat. No. 382402)

Antigen Details

Structure
G-protein coupled receptor, 7 transmembrane regions, 42 kD
Distribution

Mature B cells, Follicular helper T cells, and Burkitt's lymphoma cells.

Function
Mediates cell migration to the B cell follicles in the secondary lymphoid organs
Ligand/Receptor
CXCL13
Cell Type
B cells, Tfh
Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References
  1. Ma CS, et al. 2012. J Exp Med. 209:1241-53.
  2. León B, et al. 2012. Nat. Immunol. 13:681-90.
  3. Crotty S. 2011. Annu Rev Immunol. 29:621-63.
  4. Kerfoot SM, et al. 2011. Immunity. 34:947-60.
  5. Sáez de Guinoa J, et al. 2011. Blood. 118:1560-9.
Gene ID
643 View all products for this Gene ID
UniProt
View information about CD185 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 03/25/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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