- P83G4B6 (See other available formats)
- Regulatory Status
- Other Names
- DNM1, DNM, DMN-1, dynamin 1
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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Dynamin-1, also known as DMN-1, is a 100 kD protein with GTPase activity. Dynamin-1 is involved in several intracellular trafficking processes including synaptic vesicle recycling, neurotransmitter reuptake and receptor internalization. In addition, Dynamin-1 may be necessary for the establishment and proper maintenance of mature neuronal structure. Studies have shown that Dynamin-1 is upregulated during new neurite formation. Conversely, Dynamin-1 is downregulated during neurite retraction. Silencing the initiation codon for Dynamin limits the formation of axon-like structures.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant human Dynamin-1 (515-750a.a.) expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1:250-1:2500 diluted (0.2 – 2 µg/mL). For immunohistochemical staining on formalin-fixed paraffin-embedded tissue sections, the suggested use of this reagent is 1:100-1:250 diluted (2 – 5 µg/mL). It is recommended that the reagent be titrated for optimal performance for each application.
AB_2716194 (BioLegend Cat. No. 604001)
AB_2716195 (BioLegend Cat. No. 604002)
- 864 amino acids with a predicted molecular weight of 97 kD.
- Involved in producing microtubule bundles and able to bind and hydrolyze GTP
- Interacts with CAV1, SH3GLB1, SH3GL1, SH3GL2, SH3GL3, PHOCN, PACSIN1, PACSIN2, PACSIN3, SNX9, MYO1E, SNX33, UNC119 and DIAPH1.
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Neuroscience, Neuroscience Cell Markers
- Antigen References
- Obar RA, et al. 1990. Nature. 347:256.
- Chen-Hwang MC, et al. 2002. J Biol Chem. 277:17597.
- Grabs D, et al. 1997. J Biol Chem. 272:13419.
- Wunderlich L, et al. 1999. Cell. Signal. 11:25.
- Gene ID
- 1759 View all products for this Gene ID
- View information about Dynamin-1 on UniProt.org
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