PE/Dazzle™ 594 anti-human CD57 Recombinant Antibody

Pricing & Availability
Clone
QA17A04 (See other available formats)
Other Names
HNK-1, NK-1, Leu-7, B3GAT1
Ave. Rating
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Product Citations
publications
QA17A04_PEDazzle594_CD57_Antibody_1_012919
Human peripheral blood lymphocytes were stained with True-Stain Monocyte Blocker™ (Cat No. 425103), CD8 FITC and CD57 (clone QA17A04) PE/Dazzle™ 594 (left), or mouse IgG1, κ PE/Dazzle™ 594 isotype control (right).
  • QA17A04_PEDazzle594_CD57_Antibody_1_012919
    Human peripheral blood lymphocytes were stained with True-Stain Monocyte Blocker™ (Cat No. 425103), CD8 FITC and CD57 (clone QA17A04) PE/Dazzle™ 594 (left), or mouse IgG1, κ PE/Dazzle™ 594 isotype control (right).
  • QA17A04_PEDazzle594_CD57_Antibody_2_012919
    Human peripheral blood lymphocytes were stained with True-Stain Monocyte Blocker™ (Cat No. 425103), CD56 APC and CD57 (clone QA17A04) PE/Dazzle™ 594 (left), or mouse IgG1, κ PE/Dazzle™ 594 isotype control (right).
See PE/Dazzle™ 594 spectral data
Cat # Size Price Quantity Avail. Save
393317 25 tests £97
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393318 100 tests £215
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Description

CD57, also known as HNK-1, NK-1, and Leu-7 is a 100-115 kD oligosaccharide antigenic determinant expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans. CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8+ T cells, and is also expressed on neural cells and striated muscle. CD57 is not expressed on red blood cells, granulocytes, monocytes, or platelets. While the function of CD57 is unknown, binding to L-selectin, P-selectin, and a fragment of laminin suggests that CD57 may be involved in cell-matrix interactions. CD57 is increased in some disease states associated with CD4/CD8 imbalances (AIDS, autoimmune disease, viral infections, and allograft transplants).

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Immunogen
Membrane extract of human lymphoblastoid cell line HSB-2.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions. The solution is free of unconjugated PE/Dazzle™ 594 and unconjugated antibody.
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.

Excitation Laser
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Antigen Details

Structure
Oligosaccharide antigenic determinant present on a variety of proteins, lipds, and chrondroitin sulfate proteoglycans, 100-115 kD. The antigen is convserved across species.
Distribution

NK cells, subset of CD8+ T cells, neural cells, striated muscle

Ligand Receptor
Binds to L-selectin and P-selectin in a calcium-dependent manner, also binds to second globular domain of E8 laminin fragment.
Cell Type
NK cells, T cells
Biology Area
Cell Adhesion, Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References
  1. Schubert J, et al. 1989. In Leucocyte Typing IV (Knapp W, ed) Oxford University Press Oxford pp 711-714.
  2. Palmer BE, et al. 2005. J. Immunol. 175:8415.
  3. Schachner M, et al. 1995. Trends Neurosci. 18:183.
  4. Wood KL, et al. 2005. Clin. Immunol. 117:294.
Gene ID
27087 View all products for this Gene ID
UniProt
View information about CD57 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 01/17/2019

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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