- QA17A04 (See other available formats)
- Regulatory Status
- Other Names
- HNK-1, NK-1, Leu-7, B3GAT1
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD57, also known as HNK-1, NK-1, and Leu-7 is a 100-115 kD oligosaccharide antigenic determinant expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans. CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8+ T cells, and is also expressed on neural cells and striated muscle. CD57 is not expressed on red blood cells, granulocytes, monocytes, or platelets. While the function of CD57 is unknown, binding to L-selectin, P-selectin, and a fragment of laminin suggests that CD57 may be involved in cell-matrix interactions. CD57 is increased in some disease states associated with CD4/CD8 imbalances (AIDS, autoimmune disease, viral infections, and allograft transplants).Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Membrane extract of human lymphoblastoid cell line HSB-2.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 605™ under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Brilliant Violet 605™ excites at 405 nm and emits at 603 nm. The bandpass filter 610/20 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 605™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
- Excitation Laser
Violet Laser (405 nm)
- Product Citations
AB_2728425 (BioLegend Cat. No. 393303)
AB_2728426 (BioLegend Cat. No. 393304)
- Oligosaccharide antigenic determinant present on a variety of proteins, lipds, and chrondroitin sulfate proteoglycans, 100-115 kD. The antigen is convserved across species.
NK cells, subset of CD8+ T cells, neural cells, striated muscle
- Binds to L-selectin and P-selectin in a calcium-dependent manner, also binds to second globular domain of E8 laminin fragment.
- Cell Type
- NK cells, T cells
- Biology Area
- Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
- Schubert J, et al. 1989. In Leucocyte Typing IV (Knapp W, ed) Oxford University Press Oxford pp 711-714.
- Palmer BE, et al. 2005. J. Immunol. 175:8415.
- Schachner M, et al. 1995. Trends Neurosci. 18:183.
- Wood KL, et al. 2005. Clin. Immunol. 117:294.
- Gene ID
- 27087 View all products for this Gene ID
- View information about CD57 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD57 Reagents Request Custom Conjugation
|Purified anti-human CD57 Recombinant Antibody||QA17A04||FC,IHC-P|
|Brilliant Violet 605™ anti-human CD57 Recombinant Antibody||QA17A04||FC|
|APC anti-human CD57 Recombinant Antibody||QA17A04||FC|
|Brilliant Violet 510™ anti-human CD57 Recombinant Antibody||QA17A04||FC|
|PerCP/Cyanine5.5 anti-human CD57 Recombinant Antibody||QA17A04||FC|
|PE anti-human CD57 Recombinant Antibody||QA17A04||FC|
|PE/Cyanine7 anti-human CD57 Recombinant Antibody||QA17A04||FC|
|PE/Dazzle™ 594 anti-human CD57 Recombinant Antibody||QA17A04||FC|
|TotalSeq™-C0168 anti-human CD57 Recombinant Antibody||QA17A04||PG|
|TotalSeq™-A0168 anti-human CD57 Recombinant Antibody||QA17A04||PG|
|TotalSeq™-B0168 anti-human CD57 Recombinant Antibody||QA17A04||PG|
|Brilliant Violet 785™ anti-human CD57 Recombinant Antibody||QA17A04||FC|
|Brilliant Violet 421™ anti-human CD57 Recombinant Antibody||QA17A04||FC|
|Brilliant Violet 711™ anti-human CD57 Recombinant Antibody||QA17A04||FC|
|TotalSeq™-D0168 anti-human CD57 Recombinant Antibody||QA17A04||PG|
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human CD57 Recombinant Antibody
Brilliant Violet 605™ anti-human CD57 Recombinant Antibody
APC anti-human CD57 Recombinant Antibody
Brilliant Violet 510™ anti-human CD57 Recombinant Antibody
PerCP/Cyanine5.5 anti-human CD57 Recombinant Antibody
PE anti-human CD57 Recombinant Antibody
PE/Cyanine7 anti-human CD57 Recombinant Antibody
PE/Dazzle™ 594 anti-human CD57 Recombinant Antibody
TotalSeq™-C0168 anti-human CD57 Recombinant Antibody
TotalSeq™-A0168 anti-human CD57 Recombinant Antibody
TotalSeq™-B0168 anti-human CD57 Recombinant Antibody
Brilliant Violet 785™ anti-human CD57 Recombinant Antibody
Brilliant Violet 421™ anti-human CD57 Recombinant Antibody
Brilliant Violet 711™ anti-human CD57 Recombinant Antibody
TotalSeq™-D0168 anti-human CD57 Recombinant Antibody