- D6E10 (See other available formats)
- Other Names
- Apolipoprotein E, apolipoprotein E3, AD2, LDLCQ5, LPG, ApoE
- Mouse IgG1
- Ave. Rating
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- Product Citations
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Apo-E is a class of apolipoprotein primarily synthesized in the liver, but is also found in other tissues such as brain, kidneys, and spleen. Apo-E is a protein component of serum chylomicron and lipoprotein particles, playing essential roles in cholesterol transportation, homeostasis, and metabolism. The expression of Apo-E is induced by cholesterol-rich diets and hyperlipoproteinemia. In the central nervous system, Apo-E is produced by astrocytes and microglia. The Apo-E-containing lipoprotein particles play important functions in brain injury repair, neurogenesis, and synaptic plasticity. Apo-E has been found to be involved in the regulation of amyloid-β aggregation and clearance. Genetic polymorphisms of Apo-E are associated with neuron degenerative disorders including Alzheimer's disease.Product Details
- Antibody Type
- Host Species
- This antibody was raised against a peptide sequence corresponding to aa 141-160 of human Apo-E.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is effective in immunoblotting (WB).
(PubMed link indicates BioLegend citation)
- Munoz DG and Feldman H. 2000. CMAJ. 162(1):65-72.
- Hagberg JM, et al. 2000. Physiol Genomics. 4(2):101-108.
- Saunders AM. 2000. J Neuropathol Exp Neurol. 59(9):751-8.
- Golabek AA, et al. 2000. Biophys J. 79(2):1008-15.
- Zunarelli E, et al. 2000. Breast Cancer Res Treat. 63(3):193-8.
- Zunarelli E, et al. 2000. Clin Neuropathol. 19(1):1-6.
- Tomiyama T, et al. 1999. Cell Mol Life Sci. 6(3-4):268-79.
- Golabek AA., et al. 1996. J Biol Chem. 271(18):10602-6.
AB_2783377 (BioLegend Cat. No. 803305)
AB_2783378 (BioLegend Cat. No. 803306)
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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