APC anti-human CD198 (CCR8) Antibody

Pricing & Availability
Clone
L263G8 (See other available formats)
Other Names
CC-CKR-8,C-C CKR-8, CCR-8, CC chemokine receptor 8, CDw198, CDw198 antigen, CD198, chemokine (C-C motif) receptor 8, chemokine (C-C) receptor 8, TER1, ChemR1, and CKR-L1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
L263G8_APC_CD198_Antibody_110419_updated.png
Human peripheral blood lymphocytes were stained with CD3 PE and CCR8 (clone L263G8) APC (left) or Mouse IgG2a, κ APC isotype control (right).
  • L263G8_APC_CD198_Antibody_110419_updated.png
    Human peripheral blood lymphocytes were stained with CD3 PE and CCR8 (clone L263G8) APC (left) or Mouse IgG2a, κ APC isotype control (right).
See APC spectral data
Cat # Size Price Quantity Avail. Save
360609 25 tests £92
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360610 100 tests £215
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Description

CCR8, also known as ChemR1, TER1, and CKR-L1, belongs to the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. CCR8 is expressed on some subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. Binding with its ligand CCL1, CCR8 plays a role in the regulation of monocyte chemotaxis and thymic cell apoptosis. It has been reported that CCR8 is also a receptor for CCL18. CCR8 is also believed to be an alternative coreceptor to CD4 for HIV-1 infection.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human CCR8-transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Concentration
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood.

Excitation Laser
Red Laser (633 nm)

Antigen Details

Structure
Seven hydrophobic transmembrane domains
Distribution

Vascular smooth muscle cells, macrophages, eosinophils, peritoneal macrophages, thymocytes, T cells, Langerhans cells and neurons

Function
Regulation of monocyte chemotaxis and thymic cell apoptosis
Ligand/Receptor
CCL1, CCL18
Cell Type
Dendritic cells, Eosinophils, Langerhans cells, Macrophages, Neurons, T cells, Thymocytes
Biology Area
Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Tiffany HL, et al. 1997. J. Exp. Med. 186:165.
2. Goya I, et al. 1998. J. Immunol. 160:1975.
3. Lee S, et al. 2000. J. Virol. 74:6946.
4. Chensue SW, et al. 2001. J. Exp. Med. 193:573.
5. Qu C, et al. 2004. J. Exp. Med. 200:1231.
6. Isolam SA, et al. 2003. J. Exp. Med. 210:1889.

Gene ID
1237 View all products for this Gene ID
UniProt
View information about CD198 on UniProt.org

Related FAQs

Does staining at room temperature or even at 37°C help for checking chemokine receptors expression?

Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal.

Go To Top Version: 1    Revision Date: 10/17/2019

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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