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Alexa Fluor® 700 anti-human CD89 Antibody

Pricing & Availability
Clone
A59 (See other available formats)
Regulatory Status
RUO
Workshop
V MR30
Other Names
FcαR
Isotype
Mouse IgG1, κ
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Product Citations
publications
A59_A700_CD89_Antibody_070318
Human peripheral blood granulocytes were stained with anti-human CD89 Alexa Fluor® 700 (clone A59, filled histogram) or Mouse IgG1, κ Alexa Fluor® 700 isotype control (open histogram).
  • A59_A700_CD89_Antibody_070318
    Human peripheral blood granulocytes were stained with anti-human CD89 Alexa Fluor® 700 (clone A59, filled histogram) or Mouse IgG1, κ Alexa Fluor® 700 isotype control (open histogram).
Compare all formats See Alexa Fluor® 700 spectral data
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354117 25 tests £101
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354118 100 tests £245
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Description

CD89, also known as FcαR, is a 55-100 kD glycosylated protein.  It belongs to the immunoglobulin gene family.  It is expressed on granulocytes, monocytes, and macrophages but is absent on T cells.  It can interact with IgA aggregates and plays an important role in IgA mediated immune responses.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Ag8.653 myeloma cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

* Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633 nm / 635 nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.


Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

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Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Monteiro RC, et al. 1992. J. Immunol. 148:1764.
  2. Shen L. 1992. J. Leukoc. Biol. 51:373.
  3. Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
  4. Rogers KA, et al. 2004. Immunology 113:178.
RRID
AB_2750066 (BioLegend Cat. No. 354117)
AB_2750067 (BioLegend Cat. No. 354118)

Antigen Details

Structure
Member of the immunoglobulin gene family and is a transmembrane glycoprotein, 55-100 kD
Distribution

Granulocytes, neutrophils, eosinophils, monocytes, macrophages

Function
Interacts with IgA opsonized targets and induces immunological processes such as phagocytosis, ADCC, and release of inflammatory mediators
Ligand/Receptor
IgA (monomeric, dimeric, polymeric and secretory IgA)
Cell Type
Eosinophils, Granulocytes, Macrophages, Monocytes, Neutrophils
Biology Area
Immunology
Molecular Family
CD Molecules, Fc Receptors
Antigen References

1. Patry C, et al. 1996. J. Immunol. 156:4442.
2. de Wit, et al. 1995. J. Immunol. 155:1203.
3. Honorio-França AC, et al. 2001. J. Leukoc. Biol. 69:289.

Gene ID
2204 View all products for this Gene ID
UniProt
View information about CD89 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 07/03/2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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