- AY13 (See other available formats)
- Regulatory Status
- Other Names
- Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, HER1
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and member of the protein kinase superfamily that regulates cell growth and differentiation. EGFR binds EGF, TGF-α, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30, and vaccinia virus growth factor - all members of the EGF family. Ligand binding induces EGFR dimerization and autophosphorylation, initiating the MAPK, Akt, and JNK signaling pathways. EGFR is expressed by epithelial and endothelial cells and is frequently expressed by epithelial carcinomas.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Non-small cell lung cancer (NSCLC) cell line NCI-H322
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Yamaguchi M, et al. 2009. The 15th Annual Meeting Japan Society of Gene Therapy. p1056. Abstract 92.
AB_2650983 (BioLegend Cat. No. 352917)
AB_2650984 (BioLegend Cat. No. 352918)
- Member of the protein kinase superfamily; transmembrane glycoprotein; ligand binding induces dimerization and autophosphorylation
Epithelial cells and endothelial cells; frequently found in epithelial carcinomas
- Controls cell growth and differentiation
- MAPK, Akt, JNK
- Members of the epidermal growth factor (EGF) family such as EGF, TGF-α, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor
- Cell Type
- Endothelial cells, Epithelial cells
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, Immunology, Innate Immunity, Neuroscience, Synaptic Biology
- Molecular Family
- CD Molecules, Growth Factors
- Antigen References
1. da Cunha Santos G, et al. 2011. Annu. Rev. Pathol. 6:49.
2. Gusterson BA and Hunter KD. 2009. Lancet Oncol. 10:522.
3. Mano M and Humblet Y. 2008. Nat. Clin. Pract. Oncol. 5:415.
4. Pao W and Chmielecki J. 2010. Nat. Rev. Cancer 10:760.
- Gene ID
- 1956 View all products for this Gene ID
- View information about EGFR on UniProt.org
Related Pages & Pathways
Other FormatsView All EGFR Reagents Request Custom Conjugation
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human EGFR
PE anti-human EGFR
APC anti-human EGFR
Alexa Fluor® 488 anti-human EGFR
Brilliant Violet 421™ anti-human EGFR
PE/Cyanine7 anti-human EGFR
PerCP/Cyanine5.5 anti-human EGFR
Alexa Fluor® 594 anti-human EGFR
Alexa Fluor® 647 anti-human EGFR
Brilliant Violet 711™ anti-human EGFR
PE/Dazzle™ 594 anti-human EGFR
TotalSeq™-A0132 anti-human EGFR
Brilliant Violet 605™ anti-human EGFR
APC/Fire™ 750 anti-human EGFR
TotalSeq™-B0132 anti-human EGFR
TotalSeq™-C0132 anti-human EGFR
Biotin anti-human EGFR
TotalSeq™-D0132 anti-human EGFR