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PE anti-human CD288 (TLR8) Antibody

Pricing & Availability
Clone
S16018A (See other available formats)
Regulatory Status
RUO
Other Names
CD288, Toll-like receptor 8
Isotype
Mouse IgG2a, κ
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Product Citations
publications
S16018A_PE_CD288_Antibody_021419
Human peripheral blood monocytes were stained with CD14 Brilliant Violet 421™, treated with BioLegend’s Fixation Buffer (Cat. No. 420801) and Permeabilization Wash Buffer (Cat. No. 421002), and then stained with CD288 (TLR8) (clone S16018A) PE (left) or mouse IgG2a, κ PE isotype control (right).
  • S16018A_PE_CD288_Antibody_021419
    Human peripheral blood monocytes were stained with CD14 Brilliant Violet 421™, treated with BioLegend’s Fixation Buffer (Cat. No. 420801) and Permeabilization Wash Buffer (Cat. No. 421002), and then stained with CD288 (TLR8) (clone S16018A) PE (left) or mouse IgG2a, κ PE isotype control (right).
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395503 25 tests 142€
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395504 100 tests 288€
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Description

Toll-like receptor (TLR) 8, also known as CD288, is a 83 kDa, type 1 transmembrane protein, member of the TLR receptor family. TLR8 is expressed intracellulary in monocytes, macrophages and myeloid dendritic cells, and plays an important role in the innate immune response by binding single-stranded RNA (ssRNA). TLR8 triggers anti-viral reponses promoting the secretion of proinflammatory cytokines such as IL-12 and TNF.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human TLR8-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2801048 (BioLegend Cat. No. 395503)
AB_2801049 (BioLegend Cat. No. 395504)

Antigen Details

Structure
83 kD, Type 1 transmembrane protein
Distribution

Endosomal compartments of monocytes, macrophages, myeloid dendritic cells, and neutrophils

Function
Binds single-stranded RNA
Interaction
MYD88, TRAF6, IRAK4
Ligand/Receptor
Single-stranded GU-rich RNA
Cell Type
Dendritic cells, Macrophages, Monocytes, Neutrophils
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Toll Like Receptors
Antigen References
  1. Lood C, et al. 2017. J Exp Med. 214:2103.
  2. Prinz N, et al. 2011. Blood. 118:2322.
  3. Gringhuis SI, et al. 2010. Nat Immunol. 11419.
  4. Cros J, et al. 2010. Immunity. 33:375.
  5. Peng G, et al. 2005. Science. 309:1380.
Gene ID
51311 View all products for this Gene ID
UniProt
View information about CD288 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 02.14.2019

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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