- S16018A (See other available formats)
- Regulatory Status
- Other Names
- CD288, Toll-like receptor 8
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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Toll-like receptor (TLR) 8, also known as CD288, is a 83 kDa, type 1 transmembrane protein, member of the TLR receptor family. TLR8 is expressed intracellulary in monocytes, macrophages and myeloid dendritic cells, and plays an important role in the innate immune response by binding single-stranded RNA (ssRNA). TLR8 triggers anti-viral reponses promoting the secretion of proinflammatory cytokines such as IL-12 and TNF.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Human TLR8-transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2801048 (BioLegend Cat. No. 395503)
AB_2801049 (BioLegend Cat. No. 395504)
- 83 kD, Type 1 transmembrane protein
Endosomal compartments of monocytes, macrophages, myeloid dendritic cells, and neutrophils
- Binds single-stranded RNA
- MYD88, TRAF6, IRAK4
- Single-stranded GU-rich RNA
- Cell Type
- Dendritic cells, Macrophages, Monocytes, Neutrophils
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Toll Like Receptors
- Antigen References
- Lood C, et al. 2017. J Exp Med. 214:2103.
- Prinz N, et al. 2011. Blood. 118:2322.
- Gringhuis SI, et al. 2010. Nat Immunol. 11419.
- Cros J, et al. 2010. Immunity. 33:375.
- Peng G, et al. 2005. Science. 309:1380.
- Gene ID
- 51311 View all products for this Gene ID
- View information about CD288 on UniProt.org
Related Pages & Pathways
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other FormatsView All CD288 Reagents Request Custom Conjugation
|Purified anti-human CD288 (TLR8)||S16018A||ICFC|
|PE anti-human CD288 (TLR8)||S16018A||ICFC|
|APC anti-human CD288 (TLR8)||S16018A||ICFC|
|FITC anti-human CD288 (TLR8)||S16018A||ICFC|
|Brilliant Violet 421™ anti-human CD288 (TLR8)||S16018A||ICFC|
|PerCP/Cyanine5.5 anti-human CD288 (TLR8)||S16018A||ICFC|
|PE/Cyanine7 anti-human CD288 (TLR8)||S16018A||ICFC|
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