LPS MyD88 MyD88 MyD88 MyD88 MyD88 MyD88 c-Jun p38 JNK1 TLR1 TLR2 TLR2 TLR4 TLR4 PI3K IkB IkB TLR3 NF-kB NF-kB NF-kB NF-kB CD14 CD14 MKK6 SLAM CD80 CD83 TNF IL-18 FLIC IFN-B MyD88 LPS Toll-Like Receptors