Purified anti-human CD288 (TLR8) Antibody

Pricing & Availability
Clone
S16018A (See other available formats)
Other Names
CD288, Toll-like receptor 8
Isotype
Mouse IgG2a, κ
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Product Citations
publications
S16018A_Purified_CD288_Antibody_121918_Updated.png
Human peripheral blood monocytes were stained with CD14 Pacific Blue™, treated with BioLegend’s Fixation Buffer (Cat. No. 420801) and Permeabilization Wash Buffer (Cat. No. 421002), and then stained with purified CD288 (clone S16018A, left) or purified mouse IgG2a, κ isotype control (right), followed by anti-mouse IgG2a PE.
  • S16018A_Purified_CD288_Antibody_121918_Updated.png
    Human peripheral blood monocytes were stained with CD14 Pacific Blue™, treated with BioLegend’s Fixation Buffer (Cat. No. 420801) and Permeabilization Wash Buffer (Cat. No. 421002), and then stained with purified CD288 (clone S16018A, left) or purified mouse IgG2a, κ isotype control (right), followed by anti-mouse IgG2a PE.
Cat # Size Price Quantity Avail. Save
395502 100 µg 200€
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Description

Toll-like receptor (TLR) 8, also known as CD288, is a 83 kDa, type 1 transmembrane protein, member of the TLR receptor family. TLR8 is expressed intracellulary in monocytes, macrophages and myeloid dendritic cells, and plays an important role in the innate immune response by binding single-stranded RNA (ssRNA). TLR8 triggers anti-viral reponses promoting the secretion of proinflammatory cytokines such as IL-12 and TNF.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human TLR8-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2783317 (BioLegend Cat. No. 395502)

Antigen Details

Structure
83 kD, Type 1 transmembrane protein
Distribution

Endosomal compartments of monocytes, macrophages, myeloid dendritic cells, and neutrophils

Function
Binds single-stranded RNA
Interaction
MYD88, TRAF6, IRAK4
Ligand/Receptor
Single-stranded GU-rich RNA
Cell Type
Dendritic cells, Macrophages, Monocytes, Neutrophils
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Toll Like Receptors
Antigen References
  1. Lood C, et al. 2017. J Exp Med. 214:2103.
  2. Prinz N, et al. 2011. Blood. 118:2322.
  3. Gringhuis SI, et al. 2010. Nat Immunol. 11419.
  4. Cros J, et al. 2010. Immunity. 33:375.
  5. Peng G, et al. 2005. Science. 309:1380.
Gene ID
51311 View all products for this Gene ID
UniProt
View information about CD288 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 12.17.2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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