- 113-16 (See other available formats)
- Regulatory Status
- Other Names
- CD27 ligand, CD27L, Ki-24 antigen, Tumor necrosis factor ligand superfamily, member 7 (TNFSF7)
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD70, also known as CD27L, is a 50 kD type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily. CD70 is expressed on activated T, B and NK cells, activated plasmacytoid dendritic cells (pDCs), and chronic B cell lymphocytic leukemia and large B cell lymphomas. CD70 costimulates T cell proliferation and differentiation. It plays a role in the pDC-induced B cell differentiation. The ligand of CD70 is CD27.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- CD70-transfected L cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
Additional reported applications for the relevant formats include: blocking of plasmacytoid dendritic cell induced B cell proliferation and Ig secretion1.
(PubMed link indicates BioLegend citation)
- Shaw J, et al. 2010. Blood 115:3051. (Block)
AB_2820003 (BioLegend Cat. No. 355121)
AB_2820004 (BioLegend Cat. No. 355122)
- Type II transmembrane glycoprotein, member of the tumor necrosis factor superfamily, 50 kD
Activated T cells and B cells, activated NK cells, activated plasmacytoid dendritic cells, some B cell lymphomas
- Role in T cell proliferation, generation of cytolytic and memory T cells, B cell proliferation and differentiation
- Cell Type
- B cells, Dendritic cells, NK cells, T cells
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1. Bowman MR, et al. 1994. J. Immunol. 152:1756.
2. Shaw J, et al. 2010. Blood 115:3051.
3. Keller AM, et al. 2009. Blood 113:5167.
- Gene ID
- 970 View all products for this Gene ID
- View information about CD70 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD70 Reagents Request Custom Conjugation
|Purified anti-human CD70||113-16||FC|
|PE anti-human CD70||113-16||FC|
|FITC anti-human CD70||113-16||FC|
|PerCP/Cyanine5.5 anti-human CD70||113-16||FC|
|APC anti-human CD70||113-16||FC|
|Alexa Fluor® 647 anti-human CD70||113-16||FC|
|PE/Cyanine7 anti-human CD70||113-16||FC|
|Biotin anti-human CD70||113-16||FC|
|TotalSeq™-A0027 anti-human CD70||113-16||PG|
|TotalSeq™-C0027 anti-human CD70||113-16||PG|
|APC/Fire™ 750 anti-human CD70||113-16||FC|
|PE/Dazzle™ 594 anti-human CD70||113-16||FC|
|TotalSeq™-B0027 anti-human CD70||113-16||PG|
|TotalSeq™-D0027 anti-human CD70||113-16||PG|
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human CD70
PE anti-human CD70
FITC anti-human CD70
PerCP/Cyanine5.5 anti-human CD70
APC anti-human CD70
Alexa Fluor® 647 anti-human CD70
PE/Cyanine7 anti-human CD70
Biotin anti-human CD70
TotalSeq™-A0027 anti-human CD70
TotalSeq™-C0027 anti-human CD70
APC/Fire™ 750 anti-human CD70
PE/Dazzle™ 594 anti-human CD70
TotalSeq™-B0027 anti-human CD70
TotalSeq™-D0027 anti-human CD70