- Clone
- S18001A (See other available formats)
- Other Names
- CXCR3, G protein-coupled receptor 9 (GPR9), CKR-L2, IP10 receptor (IP10-R), Mig receptor (Mig-R)
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 splenocytes were stained with CD45R/B220 APC/Cyanine7 and CD183 (CXCR3) (clone S18001A) APC (left) or rat IgG2a, κ APC isotype control (right).
| Cat # | Size | Price | Quantity Avail. | Save | ||
|---|---|---|---|---|---|---|
| 155905 | 25 µg | 100€ | ||||
| 155906 | 100 µg | 236€ | ||||
CD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca2+ mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes, or granulocytes.
Product DetailsProduct Details
- Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse CXCR3-transfectants
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Red Laser (633 nm)
- RRID
-
AB_2814077 (BioLegend Cat. No. 155905)
AB_2814078 (BioLegend Cat. No. 155906)
Antigen Details
- Structure
- 38 kD seven pass transmembrane receptor coupled to G-protein.
- Distribution
-
T cells, plasmacytoid dendritic cells, GM-CSF activated CD34+ hematopoietic progenitors
- Function
- Essential in T cell recruitment to sites of inflammation
- Ligand/Receptor
- CXCL10, CXCL9, CXCL11 and CXCL4
- Cell Type
- Dendritic cells, Hematopoietic stem and progenitors, T cells
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
-
- Farber JM. 1997. J. Leukoc. Biol. 61(3):\246-57.
- Bonecchi R, et al. 1998. J. Exp. Med. 187(1):129-34.
- Aota K, et al. 2018. J. Oral. Pathol. Med. 12756.
- Kim B, et al. 2018. Data. Brief. 18:518-522.
- Saahene RO, et al. 2018. Cancer Biother. Radiopharm. 2450.
- Gene ID
- 12766 View all products for this Gene ID
- UniProt
- View information about CD183 on UniProt.org
Related FAQs
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