BioLegend Monocytes
Monocytes are a population of circulating white blood cells with the potential to differentiate into tissue macrophages and dendritic cells (DCs). Monocytes are derived from precursors in the bone marrow and can be subdivided into subsets that differ in size, trafficking and innate immune receptor expression. Monocytes mediate host antimicrobial defense and are also implicated in many inflammatory diseases, including atherosclerosis.

In addition, monocyte-like cells can be recruited to tumor sites and inhibit tumor-specific immune defense mechanisms. In both mice and humans, monocytes display some typical morphological features, such as irregular cell shape, oval- or kidney-shaped nuclei and cytoplasmic vesicles. However, they are still very heterogeneous and difficult to distinguish from other cells just by morphology or light scatter analysis.
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Development and Differentiation

Once in the blood stream, monocytes can enter peripheral tissues and further differentiate into macrophages or dendritic cells, depending on the environmental stimuli. Researchers have been also successful in differentiating macrophages and DCs in vitro from monocytes. Although these cells may differ from their naturally, in vivo monocyte-derived counterpart, they have been instrumental in the study of the immune system and their functions.

Click on a dropper to differentiate the monocyte in the test tube:
Dendritic cells
In vitro
derived cells
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