Alexa Fluor® 647 anti-mouse CD192 (CCR2) Antibody

Pricing & Availability
Clone
SA203G11 (See other available formats)
Regulatory Status
RUO
Other Names
Ccr2, Ckr2, Ccr2a, Ccr2b
Isotype
Rat IgG2b, κ
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Product Citations
publications
SA203G11_A647_CD192_Antibody_FC_1_080715
C57BL/6 bone marrow was stained with Ly-6G PE, CD11b FITC, and CD192 (clone SA203G11) Alexa Fluor® 647 (top image) or rat IgG2b, κ Alexa Fluor® 647 isotype control (bottom image). Dot plots are gated on Ly-6G- cells.
  • SA203G11_A647_CD192_Antibody_FC_1_080715
    C57BL/6 bone marrow was stained with Ly-6G PE, CD11b FITC, and CD192 (clone SA203G11) Alexa Fluor® 647 (top image) or rat IgG2b, κ Alexa Fluor® 647 isotype control (bottom image). Dot plots are gated on Ly-6G- cells.
  • SA203G11_A647_CD192_Antibody_FC_2_080715
Compare all formats See Alexa Fluor® 647 spectral data
Cat # Size Price Save
150603 25 µg ¥34,980
150604 100 µg ¥78,760
Description

CD192, also known as CCR2, is a 42 kD G-protein coupled receptor that is associated with bone marrow homeostasis. Specifically, CD192 mediates monocyte chemotaxis and acts as a receptor for monocyte chemoattractant protein 1 (MCP-1). CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. It is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis and cancer.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CCR2 transfectants.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.


Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.

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Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Mansouri N, et al. 2019. JCI Insight. 4:e128060. PubMed
  2. Sun G et al. 2018. Cell reports. 25(13):3786-3799 . PubMed
  3. Mariani SA, et al. 2019. Immunity. 50:1439. PubMed
  4. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  5. Guo P, et al. 2021. J Immunol. 207:408. PubMed
  6. Oladiran O, et al. 2021. J Neuroinflammation. 77:18. PubMed
  7. Pascual–García M, et al. 2019. Nat Commun. 10:2416. PubMed
  8. Blagih J, et al. 2020. Cell Rep. 30:481. PubMed
  9. Fan A, et al. 2020. J Neuroinflammation. 17:179. PubMed
  10. Wu B, et al. 2020. Int J Biol Sci. 1.132638889. PubMed
  11. Barbet G, et al. 2018. Immunity. 48:584. PubMed
  12. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  13. Peruzzotti-Jametti L, et al. 2018. Cell Stem Cell. 22:355. PubMed
  14. Chen KE, et al. 2021. J Neuroinflammation. 18:140. PubMed
  15. Oladiran O, et al. 2021. Front Immunol. 12:720733. PubMed
  16. van Ingen E, et al. 2021. Mol Ther Nucleic Acids. 26:1228. PubMed
  17. Kubli SP, et al. 2019. Nat Commun. 10:2678. PubMed
RRID
AB_2566139 (BioLegend Cat. No. 150603)
AB_2566140 (BioLegend Cat. No. 150604)

Antigen Details

Structure
G-protein-coupled receptor, 7-transmembrane protein, 42 kD.
Distribution

Monocytes/macrophages and basophils.

Function
Mediator of monocyte chemotaxis and bone marrow homeostasis.
Ligand/Receptor
MCP-1, Ccl2, Ccl7, and Ccl13.
Cell Type
Basophils, Macrophages, Monocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Mack M, et al. 2001. J. Immunol. 166:4697.
2. Dutta P, et al. 2015. Cell Stem Cell. 16:477.
3. Li L, et al. 2008. Kidney Int. 74:1526.

Gene ID
12772 View all products for this Gene ID
UniProt
View information about CD192 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 08/27/2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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