- 3G7A02 (See other available formats)
- Regulatory Status
- Other Names
- TNFRSF1B, p75, p75TNFR, TNFR2, TNFR80, TBPII
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD120b, also known as TNFRII or TNFRSF1B, belongs to the TNF receptor superfamily and can interact with ligands TNF-α and TNF-β (also known as LT-α). It is a 75 kD type I transmembrane protein expressed on lymphocytes, monocytes, and granulocytes. When present in a heterocomplex with CD120a, it induces the recruitment of anti-apoptotic molecules, c-IAP1 and c-IAP2 that possess E3 ubiquitin ligase activity. Mutations in CD120b are associated with TNF-associated periodic syndrome (TRAPS) or periodic fever syndrome.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Partial CD120b recombinant protein expressed in 293E cells (22-211aa).
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood.
* PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2820010 (BioLegend Cat. No. 358413)
AB_2820011 (BioLegend Cat. No. 358414)
- 75 kD, type I transmembrane protein, member of the TNF-receptor superfamily, forms a heterocomplex with TNFRI
Expressed on cells of hematopoietic lineage including monocytes, lymphocytes, and granulocytes
- When complexed with TNFRI, recruits anti-apoptotic molecules c-IAP1 and c-IAP2 that possess ubiquitin ligase activity; cysteine rich extracellular region
- Interacts with TTRAP and TRAF2
- TNF-α and TNF-β (LT-α)
- Cell Type
- Granulocytes, Lymphocytes, Monocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Transcription Factors
- Molecular Family
- CD Molecules
- Antigen References
1. Andrews JS, et al. 1990. J. Immunol. 144:2582.
2. Nophar Y, et al. 1990. EMBO J. 9:3269.
3. Kohno T, et al. 1990. Proc. Natl. Acad. Sci. USA 87:8331.
4. Tartaglia LA, et al. 1991. Proc. Natl. Acad. Sci. USA 88:9292.
5. Hijdra D, et al. 2012. J. Inflamm. (Lond). 9:38.
6. Chen X, et al. 2013. J. Immunol. 190:1076.
- Gene ID
- 7133 View all products for this Gene ID
- View information about CD120b on UniProt.org
Related Pages & Pathways
Other FormatsView All CD120b Reagents Request Custom Conjugation
|Purified anti-human CD120b||3G7A02||FC|
|PE anti-human CD120b||3G7A02||FC|
|APC anti-human CD120b||3G7A02||FC|
|Ultra-LEAF™ Purified anti-human CD120b||3G7A02||Neut,FC|
|Biotin anti-human CD120b||3G7A02||FC|
|PE/Cyanine7 anti-human CD120b||3G7A02||FC|
|PE/Dazzle™ 594 anti-human CD120b||3G7A02||FC|
|TotalSeq™-A1024 anti-human CD120b||3G7A02||PG|
|TotalSeq™-C1024 anti-human CD120b||3G7A02||PG|
|TotalSeq™-D1024 anti-human CD120b Antibody||3G7A02||PG|
|TotalSeq™-B1024 anti-human CD120b||3G7A02||PG|
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human CD120b
PE anti-human CD120b
APC anti-human CD120b
Ultra-LEAF™ Purified anti-human CD120b
Biotin anti-human CD120b
PE/Cyanine7 anti-human CD120b
PE/Dazzle™ 594 anti-human CD120b
TotalSeq™-A1024 anti-human CD120b
TotalSeq™-C1024 anti-human CD120b
TotalSeq™-D1024 anti-human CD120b Antibody
TotalSeq™-B1024 anti-human CD120b