- A7R34 (See other available formats)
- Regulatory Status
- Other Names
- IL-7 receptor α chain, IL-7Rα
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be an useful marker for identifying memory and effector T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cells proliferation and development.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- IL-7Ra-IgG1 fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
A7R34 is able to block clone SB/199 binding to IL-7R.
(PubMed link indicates BioLegend citation)
- Product Citations
AB_1953262 (BioLegend Cat. No. 135005)
AB_2126118 (BioLegend Cat. No. 135006)
- Type I transmembrane glycoprotein, associate with CD132, 60-90 kD
Immature B cells through early pre-B stage, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, bone marrow stromal cells
- T cell and immature B cell proliferation and development
- Cell Type
- B cells, T cells, Thymocytes
- Biology Area
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
1. Sudo T, et al. 1993. P. Natl. Acad. Sci. USA 90:9125.
2. Okuno Y, et al. 2001. P. Natl. Acad. Sci. USA 99:6246.
3. Pillai M, et al. 2004. Leukemia Lymphoma 45:2403.
- Gene ID
- 16197 View all products for this Gene ID
- View information about CD127 on UniProt.org
Related Pages & Pathways
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Other FormatsView All CD127 Reagents Request Custom Conjugation
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-mouse CD127 (IL-7Rα)
FITC anti-mouse CD127 (IL-7Rα)
PE anti-mouse CD127 (IL-7Rα)
APC anti-mouse CD127 (IL-7Rα)
PE/Cyanine7 anti-mouse CD127 (IL-7Rα)
PE/Cyanine5 anti-mouse CD127 (IL-7Rα)
Alexa Fluor® 488 anti-mouse CD127 (IL-7Rα)
Alexa Fluor® 647 anti-mouse CD127 (IL-7Rα)
PerCP/Cyanine5.5 anti-mouse CD127 (IL-7Rα)
Biotin anti-mouse CD127 (IL-7Rα)
Brilliant Violet 421™ anti-mouse CD127 (IL-7Rα)
Brilliant Violet 605™ anti-mouse CD127 (IL-7Rα)
Purified anti-mouse CD127 (IL-7Rα) (Maxpar® Ready)
PE/Dazzle™ 594 anti-mouse CD127 (IL-7Rα)
Brilliant Violet 510™ anti-mouse CD127 (IL-7Rα)
Brilliant Violet 711™ anti-mouse CD127 (IL-7Rα)
Brilliant Violet 785™ anti-mouse CD127 (IL-7Rα)
APC/Cyanine7 anti-mouse CD127 (IL-7Rα)
Brilliant Violet 650™ anti-mouse CD127 (IL-7Rα)
TotalSeq™-A0198 anti-mouse CD127 (IL-7Rα)
TotalSeq™-C0198 anti-mouse CD127 (IL-7Rα)
Ultra-LEAF™ Purified anti-mouse CD127 (IL-7Rα)
TotalSeq™-B0198 anti-mouse CD127 (IL-7Rα)