Purified anti-mouse TCR Vγ7 Antibody

Pricing & Availability
Clone
F2.67 (See other available formats)
Regulatory Status
RUO
Other Names
TCR Vgamma7, TCR Vγ5 (Garman nomenclature), TRGV7, GV4S1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
F2-67_PURE_TCR-Vy7_Antibody_120320
C57BL/6 splenocytes were stained with purified anti-mouse TCR Vγ7 (clone F2.67) (left) or purified mouse IgG2a, κ isotype control (right) followed by PE rat anti-mouse IgG2a. Cells were co-stained with FITC anti-CD3 and APC anti-γδ TCR. Data shown are CD3+ gated cells.
  • F2-67_PURE_TCR-Vy7_Antibody_120320
    C57BL/6 splenocytes were stained with purified anti-mouse TCR Vγ7 (clone F2.67) (left) or purified mouse IgG2a, κ isotype control (right) followed by PE rat anti-mouse IgG2a. Cells were co-stained with FITC anti-CD3 and APC anti-γδ TCR. Data shown are CD3+ gated cells.
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161702 500 µg 581 CHF
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Description

T cell receptor (TCR) is a heterodimer consisting of α/β chains (αβ T cells) or γ/δ chains (γδ T cells). γδ T cells are a minor T cell population in the body, with the usage of γ and δ often associated with specific anatomical localization. Vγ7-expressing γδ T cells are resident in the intestinal epithelium and contain a high proportion of extrathymically generated cells. It has been reported that butyrophilin-like molecules Btnl1 with Btnl6 are important in Vγ7+ T cell responses.

The F2.67 antibody reacts specifically with mouse TCR Vγ7 (as referred to by the Tonegawa nomenclature system for TCR γ and δ chains). Mouse TCR Vγ7 is also known as TCR Vγ5 under the Garman nomenclature system.

Several TCR γ and δ chain nomenclature systems exist. In order to consolidate the various nomenclature systems, we have created charts for corresponding names across some of the most popular naming methods. Click here to see charts.
 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Mouse hybridoma expressing anti Vγ7Vδ5 TCR
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Pereira P, et al. 2000. Eur J Immunol. 30:1988-97.
  2. Khairallah C, et al. 2015. PLoS Pathog. 11:e1004702.
  3. Di Marco Barros R, et al. 2016. Cell. 167:203-218.
Product Citations
  1. , et al. 2021. Eur J Immunol. 51:2708. PubMed
RRID
AB_2888774 (BioLegend Cat. No. 161702)

Antigen Details

Structure
Heterodimer with γ and δ chain
Distribution

Subset of γδ T cells

Function
Antigen recognition
Interaction
CD3
Cell Type
Lymphocytes, T cells, Thymocytes
Biology Area
Adaptive Immunity, Immunology, Innate Immunity
Molecular Family
TCRs
Gene ID
21641 View all products for this Gene ID
UniProt
View information about TCR Vgamma7, TCR Vγ5 (Garman nomenclature), TRGV7, GV4S1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 11.08.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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