Purified anti-human CD267 (TACI) Antibody

Pricing & Availability
1A1 (See other available formats)
Other Names
TNFRSF13B, CD267, Transmembrane Activator and CAML Interactor (TACI)
Rat IgG2a, κ
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Product Citations
Human TACI transfected cells stained with purified 1A1, followed by anti-rat IgGs-FITC
  • 1A1_Pure_042606
    Human TACI transfected cells stained with purified 1A1, followed by anti-rat IgGs-FITC
Cat # Size Price Quantity Avail. Save
311902 100 µg $175
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TACI, Transmembrane Activator CAML (calcium modulator and cyclophilin ligand) Interactor, is a 32 kD type III transmembrane protein. It belongs to TNF receptor superfamily, known as TNFRSF member 13B (TNFRSF13B) or CD267. TACI is expressed on B cells, and myeloma cells. TACI contains 2 cysteine-rich domains (CRDs). Recent studies, however, have shown that another shorter form (TACI_d2) of TACI exists wherein the N-terminal CRD is removed by alternative splicing. TACI_d2 contains full affinity for its ligands. Several proteins (BAFF/BLys, APRIL, Syndecan-2) have been identified as TACI ligands. The interaction of TACI with its ligands induces activation of the transcription factors NFAT, AP1, and NF-κ B and plays a crucial role in humoral immunity by negative regulation of B cell proliferation and survival.

Product Details
Technical data sheet

Product Details

Human, African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Host Species
TACI-transfected RBL cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Ng LG, et al.2004. J. Immunol. 173:807. (FC)
  2. Lougaris V, et al. 2012. Hum Immunol. 73:836. PubMed.
Product Citations
  1. Lougaris V, et al. 2012. Hum Immunol. 73:836. PubMed
AB_528979 (BioLegend Cat. No. 311902)

Antigen Details

Type III transmembrane protein, TNF receptor superfamily, 32 kD

B cells, meyloma cells

Negative regulation of B cell function
BAFF/BLys, April, Syndecan-2
Cell Type
B cells
Biology Area
Immunology, Costimulatory Molecules
Molecular Family
CD Molecules
Antigen References

1. Gross JA, et al. 2000. Nature 404:995.
2. Wu Y, et al. 2000. J. Biol Chem. 275:35478.
3. Yan M, et al. 2001. Nat. Immunol. 2:638.
4. Hymowitz A, et al. 2005. J. Biol. Chem. 280:7218.
5. Bischof D, et al. 2006. BLOOD 107:3235.

Gene ID
23495 View all products for this Gene ID
View information about CD267 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

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