Loading...

PerCP/Cyanine5.5 anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
Ave. Rating
Submit a Review
Product Citations
publications
M1slash70_PerCPCyanine55_CD11b_Antibody_111918
C57BL/6 splenocytes were blocked with TruStain FcX™ (anti-mouse CD16/32) Antibody then stained with Ly-6G/Ly-6C (Gr-1) APC and CD11b (clone M1/70) PerCP/Cyanine5.5 (left) or rat IgG2b, κ PerCP/Cyanine5.5 isotype control (right).
  • M1slash70_PerCPCyanine55_CD11b_Antibody_111918
    C57BL/6 splenocytes were blocked with TruStain FcX™ (anti-mouse CD16/32) Antibody then stained with Ly-6G/Ly-6C (Gr-1) APC and CD11b (clone M1/70) PerCP/Cyanine5.5 (left) or rat IgG2b, κ PerCP/Cyanine5.5 isotype control (right).
Compare all formats See PerCP/Cyanine5.5 spectral data
Cat # Size Price Quantity Check Availability Save
101227 25 µg $90
Check Availability


Need larger quantities of this item?
Request Bulk Quote
101228 100 µg $292
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PerCP/Cyanine5.5 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is = 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Additional Product Notes
BioLegend is in the process of converting the name PerCP/Cy5.5 to PerCP/Cyanine5.5. The dye molecule remains the same, so you should expect the same quality and performance from our PerCP/Cyanine5.5 products. Contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Milasan A, et al. 2017. J Am Heart Assoc. 10.1161/JAHA.117.006892. PubMed
  2. Hou X, et al. 2020. Cell Reports. 28(1):172-189.e7.. PubMed
  3. Lang J, et al. 2020. Nat Commun. 11:1338. PubMed
  4. Gordan S, et al. 2020. Cell Reports. 29(10):3033-3046.e4.. PubMed
  5. Lee T, et al. 2014. Mol Biol Cell. 25:583. PubMed
  6. Guo H, Cooper S, Friedman A, et al. 2017. PLoS One. 10.1371/journal.pone.0150809. PubMed
  7. Orberg E, et al. 2016. Mucosal Immunol. 10.1038/mi.2016.53. PubMed
  8. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  9. Shah D, et al. 2021. Oncoimmunology. 10:1939601. PubMed
  10. Zhou R, et al. 2022. EBioMedicine. 75:103762. PubMed
  11. Grandjean CL, et al. 2021. Sci Adv. 7:. PubMed
  12. Leslie J, et al. 2021. Sci Rep. 11:1415. PubMed
  13. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  14. Zhu Y, et al. 2022. Nat Commun. 13:4282. PubMed
  15. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  16. Wilden A, et al. 2022. Front Immunol. 13:991295. PubMed
  17. John S, et al. 2020. Sci Rep. 10:11377. PubMed
  18. Hastings AK, et al. 2019. iScience. 13:339. PubMed
  19. McNamara HA, et al. 2020. Cell Host Microbe. 572:28. PubMed
  20. Bouchareychas L, et al. 2021. iScience. 24(8):102847. PubMed
  21. Gern BH, et al. 2021. Cell Host Microbe. 29(4):594-606.e6. PubMed
  22. Kaczanowska S, et al. 2021. Cell. 184(8):2033-2052.e21. PubMed
  23. Kim SS, et al. 2022. Cancers (Basel). 14:. PubMed
  24. Hofmann I, et al. 2022. J Pharmacol Exp Ther. Online ahead of print. PubMed
  25. Huang X, et al. 2021. Stem Cells Int. 2021:8138374. PubMed
  26. Hong M, et al. 2021. Int J Mol Sci. 22:. PubMed
  27. Li X, et al. 2022. Nat Commun. 13:2794. PubMed
  28. Zhao X, et al. 2022. Front Mol Biosci. 9:786864. PubMed
  29. Meng W, et al. 2021. JCI Insight. 6:. PubMed
  30. Ortiz G, et al. 2020. Front Immunol. 11:1713. PubMed
  31. Postat J et al. 2018. Immunity. 49(4):654-665 . PubMed
  32. Fu B et al. 2017. Immunity. 47(6):1100-1113 . PubMed
  33. Chen L, et al. 2019. Cell Mol Gastroenterol Hepatol. 7:623. PubMed
  34. Kenichi Shimada et al. 2018. Immunity. 49(5):873-885 . PubMed
  35. Kobayashi T, et al. 2019. Cell. 176:982. PubMed
  36. Zasłona Z, et al. 2014. J Immunol. 193:4245. PubMed
  37. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  38. Dong L, et al. 2021. Cancer Cell. . PubMed
  39. Shen Y, et al. 2021. Comput Struct Biotechnol J. 19:5360. PubMed
  40. Súarez-López L, et al. 2021. iScience. 24:103406. PubMed
  41. Bauer KM, et al. 2022. JCI Insight. 7:. PubMed
  42. Yuzhu Hou et al. 2018. Immunity. 49(3):490-503 . PubMed
  43. Hirano KI, et al. 2021. eLife. 0.416666666666667. PubMed
  44. Yuan Q, et al. 2021. Cell Reports. 34(5):108724. PubMed
  45. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  46. Amano C, et al. 2015. PLoS One. 10: 0137207. PubMed
  47. Sun P, et al. 2015. J Hepatol. . PubMed
  48. Yang X, et al. 2020. Blood Sci. 2:89. PubMed
  49. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  50. Tan X, et al. 2021. Front Oncol. 11:768222. PubMed
  51. Biswas S, et al. 2021. Nature. 591:464. PubMed
  52. Khandelwal P, et al. 2013. PLoS One. 8:64193. PubMed
  53. Neubert K, et al. 2014. J Immunol. 192:5830. PubMed
  54. Schiller M, et al. 2021. Immunity. 54(5):1022-1036.e8. PubMed
  55. Zhu B, et al. 2021. Immunity. 54(6):1200-1218.e9. PubMed
  56. Pan H, et al. 2020. Mol Psychiatry. . PubMed
  57. Nguyen SL, et al. 2021. Sci Rep. 11:4217. PubMed
  58. Cai B, et al. 2021. Mol Cancer. 20:165. PubMed
  59. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  60. Xiong A, et al. 2022. EBioMedicine. 83:104239. PubMed
  61. Galle E, et al. 2022. Genome Biol. 23:207. PubMed
  62. Koh EH, et al. 2018. Diabetes. 67(12). PubMed
  63. Nakamura‐Ishizu A et al. 2018. Cell reports. 25(7):1772-1785 . PubMed
  64. Jiao H, et al. 2021. Cell. 184(11):2896-2910.e13. PubMed
  65. Lu S, et al. 2020. JCI Insight. 5:00. PubMed
  66. Anastasiou M, et al. 2021. JCI Insight. 6:. PubMed
  67. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  68. Plein A, et al. 2018. Nature. 562:223. PubMed
  69. Montel-Hagen A, et al. 2020. Cell Rep. 33:108320. PubMed
  70. Jeong SJ, et al. 2021. Autophagy. 17:3740. PubMed
  71. Fulham MA, et al. 2019. Am J Physiol Cell Physiol. 317:C687. PubMed
  72. Gu H, et al. 2018. Aging (Albany NY). 1.525694444. PubMed
  73. Cong J et al. 2018. Cell metabolism. 28(2):243-255 . PubMed
  74. JI B, et al. 2016. Cell Death Differ. 23:759-75. PubMed
  75. Bunn P, et al. 2014. J Immunol. 192:3709. PubMed
  76. Nishi C, et al. 2014. Mol Cell Biol. 34:1512. PubMed
  77. Xu G, et al. 2022. Cell Death Dis. 13:888. PubMed
  78. Raineri D, et al. 2021. Biomedicines. 10:. PubMed
  79. Park D, et al. 2020. Cancer Res. 80:4172. PubMed
  80. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  81. Pereira JA, et al. 2020. Hum Mol Genet. 29:1253. PubMed
  82. Bretscher P, et al. 2015. EMBO Mol Med. 7:593. PubMed
  83. Hu J, et al. 2020. Theranostics. 7.154166667. PubMed
  84. Qi T, et al. 2020. Cell Rep. 33:108452. PubMed
  85. Bogie JF, et al. 2020. Ther Adv Chronic Dis. 11:2040622320947378. PubMed
  86. Nayak RR, et al. 2021. Cell Host Microbe. 29(3):362-377.e11. PubMed
  87. Zhang F, et al. 2020. EMBO Mol Med. e12034:12. PubMed
  88. Lu CY, et al. 2020. J Neurosci. 40:9602. PubMed
  89. Okamura T, et al. 2021. Front Immunol. 12:669629. PubMed
  90. Qian SJ, et al. 2021. Front Immunol. 12:711337. PubMed
  91. Wang J, et al. 2021. Nat Commun. 12:6198. PubMed
  92. Fennell LM, et al. 2020. EMBO J. 39:e103303. PubMed
  93. Guo P, et al. 2021. J Immunol. 207:408. PubMed
  94. Li W, et al. 2021. Front Pharmacol. 12:697483. PubMed
  95. Yu Y, et al. 2022. Nat Commun. 13:6857. PubMed
  96. Mishra BB, et al. 2017. Nat Microbiol. 2:17072. PubMed
  97. Uribesalgo I, et al. 2019. EMBO Mol Med. 11:e9266. PubMed
  98. Xu Z, et al. 2020. Cancer Immunol Res. 1354:8. PubMed
  99. Zhu H, et al. 2021. Cell Metabolism. :. PubMed
  100. Harb H, et al. 2021. Immunity. 54(6):1186-1199.e7. PubMed
  101. Tacconi C, et al. 2021. Cell Reports. 35(2):108993. PubMed
  102. Lu S, et al. 2020. Arterioscler Thromb Vasc Biol. 40:394. PubMed
  103. Sun L, et al. 2015. J Immunol. 194:4891. PubMed
  104. Wei W, et al. 2022. mSystems. 7:e0046922. PubMed
  105. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  106. Zuo W, et al. 2022. Cell Death Discov. 8:257. PubMed
  107. Xu M, et al. 2022. Genes Dis. 9:429. PubMed
  108. Chung L et al. 2018. Cell host & microbe. 23(2):203-214 . PubMed
  109. Sasaki T, et al. 2020. Cell Reports. 28(1):202-217.e7.. PubMed
  110. Deczkowska A, et al. 2017. Nat Commun. 8:717. PubMed
  111. Sharma A, et al. 2020. Cell. 183(2):377-394.e21. PubMed
  112. Liu Z, et al. 2021. Immunity. 54(2):247-258.e7. PubMed
  113. Huang Z, et al. 2021. Nat Commun. 12:145. PubMed
  114. Carbone C, et al. 2021. J Immunother Cancer. 9:. PubMed
  115. Dagher T, et al. 2021. J Exp Med. 218:. PubMed
  116. Anger-Góra N, et al. 2021. Oncol Lett. 22:582. PubMed
  117. Coronel MM, et al. 2020. Sci Adv. 6:eaba5573. PubMed
  118. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  119. Lin W, et al. 2019. EBioMedicine. 49:133. PubMed
  120. Sendler M, et al. 2020. Gastroenterology. 158:253. PubMed
  121. Brown SM et al. 2017. Endocrinology. 158(10):3592-3604 . PubMed
  122. López MJ, et al. 2018. Invest Ophthalmol Vis Sci. 59:5671. PubMed
  123. Sydney Lavoie et al. 2019. eLife. 8 pii: e39982. PubMed
  124. Covarrubias AJ, et al. 2020. Nat Metab. 1265:2. PubMed
  125. Stowe CL, et al. 2019. eLife. 0.333333333333333. PubMed
  126. Chatterjee D, et al. 2021. Cell Reports. 35(2):108996. PubMed
  127. Grauel AL, et al. 2020. Nat Commun. 4.84375. PubMed
  128. Wu S, et al. 2022. BMC Immunol. 23:17. PubMed
  129. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  130. Zhao D, et al. 2020. Cancer Discov. 10:1374. PubMed
  131. Cruz-Herranz A, et al. 2021. JCI Insight. 6: . PubMed
  132. Gubin MM, et al. 2018. Cell. 175:1014. PubMed
  133. Wang Z et al. 2018. Immunity. 49(1):80-92 . PubMed
  134. Bhattacharya A, et al. 2018. Neuropsychopharmacology. 43:2586. PubMed
  135. Carestia A, et al. 2019. Cell Rep. 28:896. PubMed
  136. Wei Z, et al. 2021. Nat Commun. 0.805555556. PubMed
  137. Hu Y, et al. 2021. Cell Death Dis. 12:743. PubMed
  138. Chruewkamlow N, et al. 2021. Stem Cell Res Ther. 12:520. PubMed
  139. Vachon L, et al. 2022. Theranostics. 12:1440. PubMed
  140. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  141. Bravo-Caparrós I, et al. 2020. FASEB J. 34:5951. PubMed
  142. Ni C, et al. 2021. Infect Immun. 89:. PubMed
  143. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  144. Han Y, et al. 2022. Int J Biol Sci. 18:5653. PubMed
  145. Dulken BW, et al. 2019. Nature. 571:205. PubMed
  146. Muri J, et al. 2020. eLife. 9:e53627.. PubMed
  147. Winchell CG, et al. 2020. Front Immunol. 1.077083333. PubMed
  148. Yu JM, et al. 2019. Nat Commun. 4.388888889. PubMed
  149. Hightower RM, et al. 2019. Mol Ther. 28:189. PubMed
  150. Xueyang Yu et al. 2017. Immunity. 47(5):903-912 . PubMed
  151. Bitschar K, et al. 2019. Nat Commun. 10:2730. PubMed
  152. Chen Z, et al. 2019. Mol Med Rep. 19:3210. PubMed
  153. Tozuka M, et al. 2016. J Dermatol Sci. 82: 38-45. PubMed
  154. Sharif O, et al. 2013. J Immunol. 190:5640. PubMed
  155. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  156. Hsu M, et al. 2022. Nat Immunol. 23:581. PubMed
  157. Sakamoto K, et al. 2021. Immunity. 54:2321. PubMed
  158. Raoof R, et al. 2021. J Neurosci. 41:8249. PubMed
  159. Guo D, et al. 2022. Bone Res. 10:45. PubMed
  160. Bennett FC, et al. 2018. Neuron. 98:1170. PubMed
  161. Yang X, et al. 2018. Sci Rep. 8:188. PubMed
  162. Draijer C, et al. 2018. Sci Rep. 8:5105. PubMed
  163. Nagashima H et al. 2019. Immunity. 51(4):682-695 . PubMed
  164. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  165. Yousef H, et al. 2019. Nat Med. 25:988. PubMed
  166. Liu YG, et al. 2019. FASEB J. 33:5018. PubMed
  167. Da Mesquita S, et al. 2021. Science Advances. 7(21):. PubMed
  168. Unsinger J, et al. 2021. J Leukoc Biol. 109:697. PubMed
  169. Chen M, et al. 2019. Cell Stem Cell. 25:501. PubMed
  170. Muri J, et al. 2020. Cell Reports. 29(9):2731-2744.e4.. PubMed
  171. Muchenditsi A, et al. 2017. Am J Physiol Gastrointest Liver Physiol. 313:G39. PubMed
  172. Tothova Z et al. 2017. Cell stem cell. 21(4):547-555 . PubMed
  173. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  174. Dallari S, et al. 2021. Cell Host Microbe. 29(6):1014-1029.e8. PubMed
  175. Lazarian G, et al. 2021. Cancer Cell. 39(3):380-393.e8. PubMed
  176. Rustenhoven J, et al. 2021. Cell. 184(4):1000-1016.e27. PubMed
  177. Liao Y, et al. 2020. Theranostics. 7.113888889. PubMed
  178. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  179. Ding R, et al. 2022. J Neuroinflammation. 19:137. PubMed
  180. Xu JL, et al. 2022. Front Pharmacol. 13:911663. PubMed
  181. Leary N, et al. 2022. J Extracell Vesicles. 11:e12197. PubMed
  182. Hakim R, et al. 2021. J Neurosci. 41:8441. PubMed
  183. Gu H, et al. 2021. Elife. 10:. PubMed
  184. Kiss M, et al. 2020. Cancer Immunol Res. 9:309. PubMed
  185. Starr T, et al. 2018. PLoS One. 13:e0193601. PubMed
  186. Ding L et al. 2018. Cell reports. 25(11):2972-2980 . PubMed
  187. Zegarra‐Ruiz DF et al. 2018. Cell host & microbe. 25(1):113-127 . PubMed
  188. Meng Michelle Xu et al. 2017. Immunity. 47(2):363-373 . PubMed
  189. Jaitin DA et al. 2016. Cell. 167(7):1883-1896 . PubMed
  190. Zhang J, et al. 2018. Oncoimmunology. 7:e1461301. PubMed
  191. Montes de Oca M, et al. 2016. PLoS Pathog. 12: 1005398. PubMed
  192. Chen J, et al. 2017. Sci Rep. 10.1038/s41598-017-00654-2. PubMed
  193. Danzer H, et al. 2020. Elife. 9:00. PubMed
  194. Xu W, et al. 2021. Immunity. 54(3):526-541.e7. PubMed
  195. Stefan KL, et al. 2020. Cell. 1312:183. PubMed
  196. Molgora M, et al. 2020. Cell. 182:886. PubMed
  197. Werner A, et al. 2021. iScience. 24:103076. PubMed
  198. Hackstein CP, et al. 2022. Nat Commun. 13:7472. PubMed
  199. Ramanan D, et al. 2020. Cell. 181(6):1276-1290. PubMed
  200. Lee C, et al. 2020. Front Immunol. 11:77. PubMed
  201. Bohlen CJ et al. 2017. Neuron. 94(4):759-773 . PubMed
  202. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  203. Ishihara J, et al. 2018. Nat Commun. 9:2163. PubMed
  204. Maulhardt HA, et al. 2020. Invest New Drugs. 1618:38. PubMed
  205. McDonald MM, et al. 2021. Cell. 184(5):1330-1347.e13. PubMed
  206. Baptista M, et al. 2016. Nat Commun. 7:12175. PubMed
  207. Guey B, et al. 2014. Proc Natl Acad Sci U S A. 111:17254. PubMed
  208. Peng V, et al. 2022. Nat Immunol. 23:619. PubMed
  209. Piirainen S, et al. 2021. Glia. 69:2459. PubMed
  210. Chen YL, et al. 2022. Front Neurosci. 16:876582. PubMed
  211. Sakamoto K, et al. 2022. STAR Protoc. 3:101052. PubMed
  212. Tummala G, et al. 2021. Invest Ophthalmol Vis Sci. 62:41. PubMed
  213. Maller O, et al. 2020. Nat Mater. 20:548. PubMed
  214. Peltzer N, et al. 2018. Nature. 557:112. PubMed
  215. Koyama M et al. 2019. Immunity. 51(5):885-898 . PubMed
  216. Lee J, et al. 2015. Nat Commun. 6: 8499. PubMed
  217. Sen D, et al. 2016. PLoS One. 11:e0165064. PubMed
  218. Liddelow S, et al. 2017. Nature. 541:481-487. PubMed
  219. Xu Z, et al. 2020. Cell Rep. 32:108041. PubMed
  220. Ang QY, et al. 2020. Cell. 181(6):1263-1275.e16. PubMed
  221. Zheng C, et al. 2021. J Extracell Vesicles. 10:e12109. PubMed
  222. Tripathi A, et al. 2021. Mol Psychiatry. 26:3043. PubMed
  223. Guo Y, et al. 2021. Nat Immunol. 22:746. PubMed
  224. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  225. Zhang M, et al. 2022. iScience. 25:104490. PubMed
  226. Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed
  227. Pessoa Rodrigues C, et al. 2020. Sci Adv. 6:eaaz4815. PubMed
  228. Strattan E, et al. 2020. Frontiers in Immunology. 2.131944444. PubMed
  229. Ribechini E, et al. 2017. Blood Adv. 0.699305556. PubMed
  230. Tan DQ, et al. 2019. Cell Rep. 26:2316. PubMed
  231. Tong Y, et al. 2018. EBioMedicine. 39:132. PubMed
  232. Aurélien Trompette et al. 2018. Immunity. 48(5):992-1005 . PubMed
  233. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  234. Zheng H, et al. 2021. Frontiers in Immunology. 12:645100. PubMed
  235. Han J, et al. 2015. Cancer Res . 75: 5273 - 5282. PubMed
  236. Chithanathan K, et al. 2022. Biology (Basel). 11:. PubMed
  237. Wang Y, et al. 2022. Nat Cell Biol. 24:230. PubMed
  238. Erens C, et al. 2022. Biomedicines. 10:. PubMed
  239. Yang F, et al. 2021. Nat Commun. 12:3424. PubMed
RRID
AB_893233 (BioLegend Cat. No. 101227)
AB_893232 (BioLegend Cat. No. 101228)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
UniProt
View information about CD11b on UniProt.org

Related FAQs

How stable is PerCP/Cyanine5.5 tandem as compared to PerCP alone?

PerCP/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
Spark PLUS UV™ 395 anti-mouse/human CD11b M1/70 FC
Go To Top Version: 2    Revision Date: 11/19/2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login/Register
Remember me
Forgot your password? Reset Password
Request an Account