- MJ7/18 (See other available formats)
- Regulatory Status
- Other Names
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Inflamed mouse skin
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Pacific Blue™ has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue™ conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Violet Laser (405 nm)
- Application Notes
Additional reported applications include: immunoprecipitation, Western blotting, and immunofluorescence histochemistry or immunohistochemistry of acetone-fixed frozen sections2-4.
(PubMed link indicates BioLegend citation)
- Ge AZ and Butcher EC. 1994. Gene 138:201.
- Baluk P, et al. 2003. Am. J. Pathol. 163:1801. (IHC)
- Takahashi T, et al. 2003. Mol. Cell Biol. 23:1817. (IHC)
- Savinov AY, et al. 2003. J. Exp. Med. 197:643. (IHC)
- Product Citations
AB_1877185 (BioLegend Cat. No. 120411)
AB_2098890 (BioLegend Cat. No. 120412)
- Type I integral membrane protein, homodimer, TGF-β type III receptor family member
Endothelial cells, activated monocytes, macrophages, stromal cells, some cytotrophoblast
- Suppresses TGF-β signaling, angiogenesis
- TGF-β1, TGF-β3
- Cell Type
- Endothelial cells, Macrophages, Mesenchymal Stem Cells, Monocytes
- Biology Area
- Angiogenesis, Cell Adhesion, Cell Biology, Immunology, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Gougos A and M. Letarte 1988. J. Immunol. 141:1925.
2. Cheifetz S, et al. 1992. J. Bio. Chem. 267:19027.
3. Barbara NP, et al. 1999. J. Bio. Chem. 274:584.
4. Lastres P, et al. 1992. Eur. J. Immunol. 22:393.
5. Duff S, et al. 2003. FASEB J. 17:984.
6. Warrington K, et al. 2005. Anticancer Res. 25:185.
- Gene ID
- 13805 View all products for this Gene ID
- View information about CD105 on UniProt.org
|Purified anti-mouse CD105||MJ7/18||FC, IHC-F, WB, IP|
|Biotin anti-mouse CD105||MJ7/18||FC|
|Alexa Fluor® 488 anti-mouse CD105||MJ7/18||FC|
|PE anti-mouse CD105||MJ7/18||FC|
|PE/Cyanine7 anti-mouse CD105||MJ7/18||FC|
|Pacific Blue™ anti-mouse CD105||MJ7/18||FC|
|APC anti-mouse CD105||MJ7/18||FC|
|PerCP/Cyanine5.5 anti-mouse CD105||MJ7/18||FC|
|Alexa Fluor® 594 anti-mouse CD105||MJ7/18||IHC-F|
|Alexa Fluor® 647 anti-mouse CD105||MJ7/18||IHC-F|
|TotalSeq™-A0812 anti-mouse CD105||MJ7/18||PG|
|PE/Dazzle™ 594 anti-mouse CD105||MJ7/18||FC|
|APC/Fire™ 750 anti-mouse CD105||MJ7/18||FC|
|PE/Cyanine5 anti-mouse CD105||MJ7/18||FC|
|TotalSeq™-C0812 anti-mouse CD105||MJ7/18||PG|
|APC/Cyanine7 anti-mouse CD105||MJ7/18||FC|
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-mouse CD105
Biotin anti-mouse CD105
Alexa Fluor® 488 anti-mouse CD105
PE anti-mouse CD105
PE/Cyanine7 anti-mouse CD105
Pacific Blue™ anti-mouse CD105
APC anti-mouse CD105
PerCP/Cyanine5.5 anti-mouse CD105
Alexa Fluor® 594 anti-mouse CD105
Alexa Fluor® 647 anti-mouse CD105
TotalSeq™-A0812 anti-mouse CD105
PE/Dazzle™ 594 anti-mouse CD105
APC/Fire™ 750 anti-mouse CD105
PE/Cyanine5 anti-mouse CD105
TotalSeq™-C0812 anti-mouse CD105
APC/Cyanine7 anti-mouse CD105