- HIP8 (See other available formats)
- Regulatory Status
- IV P38
- Other Names
- gpIIb, CD41a
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD41 is a 125/25 kD α subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIbα) and light chain (gpIIbβ) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, and thrombin.Product Details
- Verified Reactivity
- Reported Reactivity
- African Green, Baboon, Capuchin Monkey, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 700 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 700 has a maximum emission of 719 nm when it is excited at 633 nm / 635 nm. Prior to using Alexa Fluor® 700 conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and blocking of platelet aggregation2. The HIP8 antibody has been reported to block the activation of platelets by various stimuli, including collagen, and ADP.
(PubMed link indicates BioLegend citation)
- Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
- McCarty OJT, et al. 2000. Blood 96:1789.
- Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
- Zhi L et al. 2013. PLoS One. 8:e79869. (IHC)
- Product Citations
AB_2566538 (BioLegend Cat. No. 303727)
AB_2566539 (BioLegend Cat. No. 303728)
- Integrin family, α subunit of CD41/CD61 (GPIIb-IIIa) complex, 125/22 kD
- Platelet aggregation, platelet attachment to extracellular matrix
- Fibrinogen, fibronectin, von Willebrand factor, thrombin
- Cell Type
- Megakaryocytes, Platelets
- Biology Area
- Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Denzin L, et al. 1996. J. Exp. Med. 184:2153.
2. Denzin L, et al. 1995. Cell 82:155.
3. Riberdy J, et al. 1994. J. Cell Biol. 125:1225.
- Gene ID
- 3674 View all products for this Gene ID
- View information about CD41 on UniProt.org
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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APC anti-human CD41
FITC anti-human CD41
PE anti-human CD41
PE/Cyanine5 anti-human CD41
Purified anti-human CD41
Pacific Blue™ anti-human CD41
APC/Cyanine7 anti-human CD41
PE/Cyanine7 anti-human CD41
PerCP/Cyanine5.5 anti-human CD41
Purified anti-human CD41 (Maxpar® Ready)
Alexa Fluor® 647 anti-human CD41
Alexa Fluor® 700 anti-human CD41
Alexa Fluor® 488 anti-human CD41
Brilliant Violet 421™ anti-human CD41
PE/Dazzle™ 594 anti-human CD41
Brilliant Violet 510™ anti-human CD41
Biotin anti-human CD41
TotalSeq™-A0353 anti-human CD41
TotalSeq™-C0353 anti-human CD41
Brilliant Violet 785™ anti-human CD41
Brilliant Violet 605™ anti-human CD41
Ultra-LEAF™ Purified anti-human CD41
TotalSeq™-B0353 anti-human CD41 Antibody
APC/Fire™ 750 anti-human CD41 Antibody
TotalSeq™-D0353 anti-human CD41