- GB11 (See other available formats)
- Other Names
- Granzyme-2, serine protease B, CCP1, Asp-ase, CTLA-1
- Mouse IgG1, κ
- Ave. Rating
- 4 reviews
- Product Citations
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Granzyme B is a 32 kD serine protease, also known as granzyme-2, serine protease B, CCP1, Asp-ase, and CTLA-1. Granzyme B is abundantly stored in the granules of cytotoxic T lymphocytes and NK cells. Low level of expression has been reported in granulocytes, B cells, and activated dendritic cells. Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor.Product Details
- Human, Mouse, Cross-Reactivity: Rat
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 647.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses
- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Product Citations
AB_2294995 (BioLegend Cat. No. 515405)
AB_2566333 (BioLegend Cat. No. 515406)
- 32 kD serine protease
Cytotoxic T-cells and NK cells, low on granulocytes, B cells and activated dendritic cells
- Induction of cell death and apoptosis
- Ligand Receptor
- Mannose-6-phosphate receptor
- Cell Type
- T cells, NK cells, B cells, Dendritic cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroscience
- Molecular Family
- Proteases, Enzymes and Regulators
- Antigen References
1. Estebanez-Perpina E, et al. 2000. Biol Chem. 381:1203
2. Griffiths GM. And S. Isaaz, et al. 1993. J. Cell Biol. 120:885
3. Spaeny-Dekking EH, et al. 1998. J. Immunol. 160:3610
4. Wagner C, et al. 2008. Mol. Immunol. 45:1761
- Gene ID
- 3002 View all products for this Gene ID 14939 View all products for this Gene ID 171528 View all products for this Gene ID
- View information about granzyme b on UniProt.org
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