- A17084A (See other available formats)
- Other Names
- Vacuolar protein sorting-associated protein 35
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
|Cat #||Size||Price||Quantity Avail.||Save|
VPS35 is the largest subunit of the retromer complex, which plays an important role in retrograde protein transport from the endosome to the trans-Golgi network. VPS35 binds to VPS26 (VPS26A or VPS26B) and VPS29 to form the vacuolar protein sorting subcomplex (VPS), which in turn interacts with different nexins to form different retromer variants that transport different targets. D620N mutation in VPS35 has been implicated as a causative genetic factor for developing late-onset, autosomal dominant familial Parkinson’s disease, and could serve as potential therapeutic target for PD.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2783456 (BioLegend Cat. No. 856401)
AB_2783457 (BioLegend Cat. No. 856402)
- VPS35 is a 796 amino acid protein with an apparent molecular mass of ~92 kD.
Tissue Distribution: Ubiquitously expressed in all tissues.
Cellular Distribution: Cytosol, lysosome, endosome, and secreted.
- Largest subunit of the retromer complex involved in retrograde transport of proteins from endosomes to the trans-Golgi network.
- VPS26 (VPS26A or VPS26B), VPS29, SNX1, SNX2, IGF2R, SNX3, GOLPH3, LRRK2, SLC11A2, SNX27, RAB7A.
- Biology Area
- Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
- Molecular Family
- Organelle Markers
- Antigen References
- Cui Y, et al. 2018. FEBS Lett. 592(7):1096
- Williams ET, et al. 2017. J Parkinsons dis. 7(2):219
- Ferreira M, et al. 2017. Acta Neurol Scand. 135(3):273
- Gene ID
- 55737 View all products for this Gene ID 65114 View all products for this Gene ID 25479 View all products for this Gene ID
- View information about VPS35 on UniProt.org
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.