- Prk 8 (See other available formats)
- Regulatory Status
- Other Names
- PARK2, AR-JP, LPRS2, PDJ, PRKN, E3 ubiquitin-protein ligase parkin, Parkin 2, E3 ubiquitin ligase, parkinson disease protein 2, parkinson juvenile disease protein 2, Parkinson disease (autosomal recessive, juvenile) 2, parkin
Signet Catalog# 9530-02
Signet Catalog# 9530-05
Signet Catalog# 9530-10
Covance Catalog# SIG-39530
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
Parkin (also known as PARK2, AR-JP, PRKN) is a protein encoded by the PARK2 gene in humans. It is a component of the E3 ubiquitin ligase complex that mediates the targeting of proteins for degradation. Mutations in the PARK2 gene cause a familial form of Parkinson’s disease called autosomal recessive juvenile Parkinson’s disease (AR-JP).Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Phosphate-buffered solution (no preservatives or carrier proteins).
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
WB - Quality tested
ICC, IHC-P - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is reactive to the R2 domain of human and murine parkin.
(PubMed link indicates BioLegend citation)
- Tay SP, et al. 2018. J Biol Chem. 285: 29231-29238. (WB, ICC)
- Pawlyk AC, et al. 2003. J Biol Chem. 278(48):48120-8. (WB, IHC-P)
AB_2810708 (BioLegend Cat. No. 808504)
AB_2564744 (BioLegend Cat. No. 808501)
AB_2564745 (BioLegend Cat. No. 808502)
AB_2564743 (BioLegend Cat. No. 808503)
- Biology Area
- Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance
- Molecular Family
- Mitochondrial Markers
- Gene ID
- 5071 View all products for this Gene ID
- View information about Parkin on UniProt.org
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