- A18072A (See other available formats)
- Other Names
- NRAS Proto-Oncogene, GTPase NRas, Neuroblastoma RAS Viral Oncogene Homolog
- Mouse IgG2b, κ
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- Product Citations
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NRAS is a Ras gene family member originally identified in human neuroblastoma cells. Like other members of the Ras family, NRAS has GTP/GDP binding and GTPase activity, and functions as a G-like regulatory protein that plays a role in regulating cell growth. Mutations in NRAS have been shown to transform cultured cells to tumor cells, implicating its role in tumorigeneses, as potential therapeutic target for cancers such as melanoma.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant human NRAS a.a. 1-186
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For immunohistochemistry, a concentration range of 2.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- NRAS is a 189 amino acid protein with predicted and observed molecular mass of ~ 21 kD.
Tissue Distribution: Ubiquitously expressed. Highly expressed in appendix, gallbladder, and gastrointestinal tract.
Cellular Distribution: Plasma membrane, Golgi apparatus, cytosol, and nucleus.
- G-Like regulatory protein that plays a role in regulating cell growth.
- RGS14, RASSF7
- GTP, GDP
- Cell Type
- Astrocytes, Endothelial cells, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Oligodendrocytes
- Biology Area
- Cancer Biomarkers, Cell Biology, Cell Proliferation and Viability, Neuroscience, Stem Cells
- Molecular Family
- Antigen References
- Rocks O, et al. 2005. Science. 307:1746-52.
- Byrne M, Saif MW. 2019. Onco. Targets Ther. S194605
- Sexton RE, et al. 2019. Semin. Cancer Biol. 54:131-7.
- Gene ID
- 4893 View all products for this Gene ID 24605 View all products for this Gene ID
- View information about NRAS on UniProt.org
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