- Poly28608 (See other available formats)
- Other Names
- RNA-binding protein Nova-1, Neuro-oncological ventral antigen 1, Onconeural ventral antigen 1, Paraneoplastic Ri antigen, Ventral neuron-specific protein 1, Nova-1
- Rabbit Polyclonal IgG
- Ave. Rating
- Submit a Review
- Product Citations
|Cat #||Size||Price||Quantity Avail.||Save|
RNA binding-protein Nova-1(NOVA1) is a brain-specific splicing factor well conserved in vertebrates. It was first identified as an antigen in paraneoplastic opsoclonus-myoclonus ataxia (POMA), a disorder related to breast cancer and motor dysfunction. Nova1 binds to a specific sequence cluster in the brain to regulate neuronal pre-mRNA splicing. Nova1-binding sequences are 94% identical in vertebrates, suggesting the binding is sequence dependent. Nova1 null mice die postnatally from motor deficits associated with neuronal cell death in spinal cord and brain stem.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant NOVA1 (Ala295-Gly510) with two N-terminal tags.
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.05 - 0.5 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Multiple bands observed on WB correspond to different NOVA1 splice variants (1).
- Human NOVA1 is a 507 amino acid protein with a predicted molecular mass of ~51 kD.
Tissue distribution: Brain
Cellular distribution: Nucleus
- NOVA1 regulates RNA-splicing in neurons.
- Interacts with PTBP2.
- Cell Type
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Neurodegeneration, Neuroscience
- Molecular Family
- Antigen References
- Jelen N, et al. 2007. PLOS Genet. 3(10):e173
- Buckanovich RJ, et al. 1997. Mol Cell Biol. 17(6):3194-201.
- Jensen KB, et al. 2000. Neuron. 2000. 25(2):359-71.
- Gene ID
- 4857 View all products for this Gene ID
- View information about NOVA1 on UniProt.org
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.