- 22H9 (See other available formats)
- Regulatory Status
- Other Names
- Thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, CRLF2, IL-XR, TSLP-R
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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TSLP-R, also known as the thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, and IL-XR, is a 40kD type I membrane receptor that forms a functional heterodimeric complex with IL-7R and binds with TSLP. TSLPR is required for proper protein folding and a box1 motif important for association with the JAKs. TSLP-R is expressed in myeloid cells, dendritic cells, B cells and activated monocytes. It is weakly expressed in T cells. Expression has also been reported in heart, skeletal, muscle, and kidney tissues. Ligand receptor interactions have been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergy diseases.Product Details
- Antibody Type
- Host Species
- TSLP Receptor Protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Isaksen DE, et al. 2002. J. Immunol. 168:3288. (FC)
- Bell BD, et al. 2013. Nat. Immunol. 14:364. (FC)
- Iseki M, et al. 2012. International Immunology 24:183. (FC)
- Astrakhan A, et al. 2007. Nature Immunology 8:522. (FC)
AB_2616861 (BioLegend Cat. No. 151802)
- Type I membrane receptor, forms functional heterodimeric complex with IL-7R to bind TSLP. Contains WSXWS motif required for proper protein folding and a box1 motif that is important for association with the JAKs.
- Expressed preferentially in myeloid cells including dendritic cells, B cells, activated monocytes, weakly expressed in T cells. Also expressed in heart, skeletal, muscle, and kidney cells.
- Binds to TSLP to stimulate cell proliferation.
- Cell Type
- Dendritic cells, B cells, Monocytes
- Biology Area
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
1. Reche PA, et al. 2001. J. Immunol. 167:336.
2. Tonozuka Y, et al. 2001. Cytogenet. Cell Genet. 93:23.
3. Zhang W, et al. 2001. Biochem. Biophys. Res. Commun. 281:878.
4. Wang YH, et al. 2006. Immunity 24:827.
- Gene ID
- 57914 View all products for this Gene ID
- View information about TSLPR on UniProt.org
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