Purified anti-mouse NK-1.1 Recombinant Antibody

Pricing & Availability
Clone
QA19A51 (See other available formats)
Regulatory Status
RUO
Other Names
NKR-P1C, NKR-P1B, Ly-55, CD161, CD161b, CD161c
Isotype
Rat IgG2a, κ
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Product Citations
publications
QA19A51_PURE_NK1dot1_Recombinant_Antibody_v2_052121.png
C57BL/6 mouse splenocytes were stained with CD49b (DX5) APC and purified NK1.1 recombinant (clone QA19A51) (left) or purified rat IgG2a, κ isotype control (right), followed by anti-rat IgG2a PE.
  • QA19A51_PURE_NK1dot1_Recombinant_Antibody_v2_052121.png
    C57BL/6 mouse splenocytes were stained with CD49b (DX5) APC and purified NK1.1 recombinant (clone QA19A51) (left) or purified rat IgG2a, κ isotype control (right), followed by anti-rat IgG2a PE.
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161902 100 µg £34.00
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Description

NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Recombinant
Host Species
Rat
Immunogen
NK-1+ cells from mouse spleen and bone marrow
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2892331 (BioLegend Cat. No. 161902)

Antigen Details

Structure
NKR-P1 gene family
Distribution

NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB/N, NZB)

Function
NK cell activation, IFN-γ production, cytotoxic granule release
Interaction
NK cells, NKT cells
Cell Type
NK cells, NKT cells
Biology Area
Immunology, Innate Immunity
Antigen References
  1. Lanier LL. 1997. Immunity. 6:371.
  2. Yokoyama WM, et al. 1993. Ann Rev Immunol. 11:613.
  3. Koo GC, et al. 1986. J Immunol. 137:3742.
  4. Giorda R, et al. 1991. J Immunol. 147:1701.
Gene ID
17059 View all products for this Gene ID
UniProt
View information about NK-1.1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 05/21/2021

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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