Purified anti-mouse CD91 Antibody

Pricing & Availability
Clone
W19299B (See other available formats)
Regulatory Status
RUO
Other Names
LRP1, LDL Receptor Related Protein 1
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
W19299B_PURE_CD91_Antibody_090822
Thioglycolate-elicited Balb/c mouse peritoneal macrophages were stained with anti-mouse F4/80 APC and purified anti-mouse CD91 (left) or purified rat IgG2b, κ isotype control (right) followed by PE anti-rat IgG2b.
  • W19299B_PURE_CD91_Antibody_090822
    Thioglycolate-elicited Balb/c mouse peritoneal macrophages were stained with anti-mouse F4/80 APC and purified anti-mouse CD91 (left) or purified rat IgG2b, κ isotype control (right) followed by PE anti-rat IgG2b.
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111902 100 µg £274
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Description

CD91, also known as LRP1, is a transmembrane endocytic and cell signaling protein that regulates diverse cellular functions in the brain, liver, kidney, lung, and vasculature. The alpha and beta chains of LRP1 form a transmembrane receptor on the plasma membrane that plays a role in receptor-mediated endocytosis and lipoprotein metabolism. LRP1 gene encodes a 4545 amino acid precursor protein that is processed in the trans-Golgi complex into the 505 kD. It is involved in phagocytosis of apoptotic cells and cellular liquid homeostasis, as well as the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin). CD91 is also essential to the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. CD91 acts as an alpha-2-macroglobulin receptor and TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread and is required for early embryonic development.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2927861 (BioLegend Cat. No. 111902)

Antigen Details

Structure
505 kD with 4545 a.a.
Distribution

Tissue Distribution: brain, lung, adipose tissue, and reproductive system

Cellular Distribution: plasma membrane, nucleus, cytosol, lysosome, and endosome

Function
Endocytosis, phagocytosis of apoptotic cells, cellular lipid homeostasis
Interaction
LRPAP1, TAU/MAPT
Ligand/Receptor
Alpha-2-macroglobulin receptor and TAU/MAPT receptor
Cell Type
Macrophages, Microglia, Oligodendrocytes
Biology Area
Cell Motility/Cytoskeleton/Structure, Immunology, Protein Trafficking and Clearance, Signal Transduction
Molecular Family
Apolipoproteins, Tumor Suppressors
Antigen References
  1. Herz J, et al. 1992. Cell. 71:411-21.
  2. Jennifer N.R., et al. 2020. Natural. 580(7803):381.
Gene ID
16971 View all products for this Gene ID
UniProt
View information about CD91 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 09/08/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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