Purified anti-mouse β2-microglobulin Antibody

Pricing & Availability
Clone
A16041A (See other available formats)
Other Names
Ly-m11, beta2m, beta2-m
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
A16041A_PURE_beta2-microglobulin_Antibody_062019
C57BL/6 mouse splenocytes were stained with purified anti-mouse B2M (clone A16041A; filled histogram) or with purified rat IgG2a, κ isotype control (open histogram), followed by PE goat anti-rat IgG.
  • A16041A_PURE_beta2-microglobulin_Antibody_062019
    C57BL/6 mouse splenocytes were stained with purified anti-mouse B2M (clone A16041A; filled histogram) or with purified rat IgG2a, κ isotype control (open histogram), followed by PE goat anti-rat IgG.
Cat # Size Price Quantity Avail. Save
154502 500 µg £218
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Description

Beta 2-microglobulin (β2M) is a 12 kDa, Ig like, non-membrane-anchored glycoprotein. It non-covalently associates with MHC class I heavy chain and some Class I-like molecules and serves as the light chain. In association with MHC class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role in stabilizing MHC class I complexes for antigen presentation. In humans, circulating β2M levels are elevated in autoimmune/inflammatory disorders, viral infections, and glomerular filtration disorders.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant Mouse B2M
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
12 kD, Ig like glycoprotein
Distribution

Leukocytes, platelets, endothelial cells, epithelial cells

Function
Component of MHC class I complex
Ligand/Receptor
TCR (through MHC class I)
Cell Type
Endothelial cells, Epithelial cells, Leukocytes, Platelets
Biology Area
Immunology
Molecular Family
MHC Antigens
Antigen References
  1. Bernier GM, 1980, ox Sang, 38:323.
  2. Williams A, et al, 2002, Tissue Antigens, 59:3.
  3. Williams DB, et al, 1989, J. Immunol, 142:2796.
  4. Benoit LA, et al. 2007, J Immunol, 179:3588.
Gene ID
12010 View all products for this Gene ID
UniProt
View information about beta2-microglobulin on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 06/20/2019

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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