- W18144A (See other available formats)
- Other Names
- Hypoxia Up-Regulated 1, GRP-170, ORP-150, 170 kD Glucose-Regulated Protein 150 kD Oxygen-Regulated Protein
- Rat IgG2a, κ
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HYOU1 belongs to the heat shock protein 70 family. The protein encoded by this gene is involved in stress-dependent induction. As a result, under low-oxygen conditions, HYOU1 accumulates in the endoplasmic reticulum. HYOU1 also acts as a nucleotide exchange factor (NEF) that recognizes other proteins within the ER and participates in protein folding.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Partial recombinant human HYOU1 protein corresponding to amino acids 750-999.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC, IP - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.05 - 1.0 µg per ml. For immunocytochemistry, a concentration of 1.0 μg per ml is recommended. For immunoprecipitation, the suggested use of this reagent is 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
When stained for ICC, methanol permeabilization proved more effective than Triton-X 100 permeabilization in localizing expression to the endoplasmic reticulum.
AB_2814532 (BioLegend Cat. No. 671401)
AB_2814533 (BioLegend Cat. No. 671402)
- HYOU1 is a 999 amino-acid protein with a predicted molecular weight of 110 kD.
Localized to the ER; Ubiquitously expressed
- Protein folding & secretion; stress-dependent induction
- Molecular Family
- Heat Shock Proteins, Organelle Markers
- Antigen References
- Ozawa K, et al. 1999. J. Biol. Chem. 274(10):6397-404.
- Ikeda J, et al. 1997. Biochem. Biophys. Res. Commun. 230(1):94-9.
- Takeuchi S. 2006. Protein J. 25(7-8):517-28.
- Kaneda S, et al. 2000. J Biochem. 128(3):529-38.
- Gene ID
- 10525 View all products for this Gene ID
- View information about HYOU1 on UniProt.org
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