- 5B5 (See other available formats)
- VI CD77.5
- Other Names
- globotriaosylcermamide (Gb3), Burkitt's lymphoma associated antigen (BLA), cermadie trihexoside (CTH), and Pk blood group antigen
- Mouse IgM, κ
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- Product Citations
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CD77, also known as Gb3, is a type II membrane protein. It was found specifically expressed on Burkitt's lymphoma cells and on a subset of germinal center B lymphocytes. CD77 has been described as a receptor for Shiga Toxin and Verotoxin 1 (VT1), which is produced by Shigella dysenteriae and some strains of E. coli. It is used as a marker for germinal center stage B-cells. CD19 has been reported as a ligand for D77 and their interaction functions in adhesion and signal transduction at a specific stage of B cell development. Studies have shown that cross-linking CD77 induces apoptosis in some B cell lines.Product Details
- Antibody Type
- Host Species
- Human peripheral blood mononuclear cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
WB, IHC-F - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for relevant formats) include: Western blotting1 and immunohistochemical staining of frozen tissue sections1.
(PubMed link indicates BioLegend citation)
- Fyfe G, et al. 1987. J. Immunol. 139:2187. (WB, IHC)
AB_2561846 (BioLegend Cat. No. 357101)
AB_2561847 (BioLegend Cat. No. 357102)
- Type II membrane protein
Burkitt's lymphoma cells, a subset of germinal center B lymphocytes
- Involved in cell adhesion and signaling transduction by binding CD19
- Receptor of Shiga Toxin and Verotoxin 1 (VT1) and CD19
- Cell Type
- B cells, Lymphocytes
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Tétaud C, 2003. J. Biol. Chem. 278:45200.
2. Maloney MD, 1994. J. Exp. Med. 1994 180:191.
3. Mangeney M, et al. 1991. Eur. J. Immunol. 21:1131.
4. Mangeney M, et al. 1993. Cancer Res. 53:5314.
- Gene ID
- 53947 View all products for this Gene ID
- View information about CD77 on UniProt.org
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